Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   3RD WEEK SEPTEMBER 2014 , Volume 32 , Number 294; Page(s) 1 To 10.
 
Paper: 

CLINICAL STUDIES REGARDING RELATION OF INSULIN RESISTANT SYNDROME AND COLORECTAL POLYPS IN PEOPLE WITH 50 YEAR AND MORE

 
 
Author(s):  HEMMAT AHMAD REZA, SOBHANI AHMAD, FALLAH ZEYNAB, TORABI ZAHRA, FOULADI LOTFOLLAH, RAFIEI RAHMATOLLAH*
 
* DEPARTMENT OF INTERNAL MEDICINE, SCHOOL OF MEDICINE, ISLAMIC AZAD UNIVERSITY, NAJAFABAD BRANCH, ISFAHAN, IRAN
 
Abstract: 

Background: Insulin resistance is a condition in the form of the lack of sensitivity of the tissues for removing glucose. Colorectal polyps with the histology basis has the risk in transforming to the malignant neoplastic form. There are some uncontrollable risk-factors that influence the immergence colorectal neoplasms, though some of them are relatively controllable, among which the insulin resistance could be named. The aim of this investigation is analyzing the relation between insulin resistance and affecting to colorectal neoplasms in the people with 50 years of age or more.
Methods: This study was done in descriptive-analytic cross-sectional study method on 200 patients with 50 years of age and older, with indications of colonoscopy and without the risk factors such as family history of colon, affecting to cancer, intestinal inflammation, anemia, rectal bleeding and so on. BP, waist circumference, height and weight of patients were measured. Their HDL, FBS, TG and plasma insulin were controlled and then, they underwent colonoscopy. In case of observing any abnormal disorders, the samples were sent for pathological controls. Finally, the recorded data was analyzed by SPSS21 software.
Findings: The results of the research show that the frequency of colorectal polyps are more in 50 year old people affected by insulin resistance syndrome (P value
=0.007). There are significant relations between the affected people to insulin resistance syndrome, the people with raised fasting blood suger, the ladies with low HDL and metabolic syndrome with adenoma with advanced pathology (P<0.05), but no significant relation exists in cases with hypertension, age, sex, obesity and hypertriglyceridemia (P>0.05).
Conclusion: This study shows that the frequency of colorectal polyps, especially the advanced pathology is observed more in the people affected to insulin resistance, diabetic people or the people who are susceptible to diabetes. It is recommended for the mentioned patients to have investigations of colonoscopy in younger ages to prevent deaths due to colorectal cancer. It is also necessary to have more investigations in this regard.

 
Keyword(s): INSULIN RESISTANCE SYNDROME, METABOLIC SYNDROME, COLORECTAL POLYP
 
References: 
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