This paper discusses the loyalty of spouses within the framework of Islamic. First, the issue will be investigated through semantic approach. Then, based on Quran, the strength of marriage and living on the basis of God`s will be discussed as the spouses' loyalty measures. By taking care of these measures and looking at loyalty as a way of protecting the faith, the loyalty spirit will be found in all the aspects of mutual life. Staying loyal to the spouse will be reflected in many aspects of life and has an important role in the physical and mental health of the family. Based on Quran, there is no permit for disloyalty in the marriage commitments and duties.