Alhagi maurorum is medicinal plant and belongs to legume species which is commonly known as Camel thorn. Plant essences have been studied with respect to their antiviral effects. It has been observed that the majority of the essences extracted from plants comprise antifungal, anti-parasitic, and antimicrobial properties. The present study was carried out in two replications, in an attempt to investigate the impact of aqueous-alcoholic extract of alhagi maurorum on deactivating O, Asia, and C serotypes of FDM’s virus. FMD is a fast-spreading viral disease which attacks even-hooves animals. The toxic degree of refined aqueous-alcoholic extract at 1.5, 1.10, 1.20, 1.80, up to 1.1280 concentrations was determined by means of IBRS2 cell and neutral red color. On the basis of the results, it can be argued that there was no significant difference between the amount of virus which was exposed to different concentrations of alhagi maurorum’s aqueous-alcoholic extract and the control virus at 37 and 25 degree centigrade. Hence, the aqueous-alcoholic extract of alhagi maurorum does not have a preventing or neutralizing effect on the spread or infection of O, Asia, and C serotypes of FDM’s virus.