Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   JULY-AUGUST 2014 , Volume 21 , Number 3; Page(s) 485 To 491.
 
Paper: 

PROGNOSTIC VALUE OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN-6 AND CLINICAL OUTCOME IN PATIENTS WITH SEVERE HEAD INJURY

 
 
Author(s):  YOUSEFZADEH SHAHROKH, DEHNADI MOGHADAM ANOOSH, KAZEMNEZHAD LEILI EHSAN, HOSEINPOUR MARIEH, SANEEI ZAHRA, MOHTASHAM AMIRI ZAHRA*
 
* SYDNEY UNIVERSITY, GUILAN ROAD TRAUMA RESEARCH CENTER, MEDICAL FACULTY OF GUILAN UNIVERSITY, RASHT, IRAN
 
Abstract: 

Background: Damage caused by traumatic brain injury (TBI) depends on the extent of primary and secondary damages. The latter can cause induced neurological inflammation by releasing pro- and anti-inflammatory cytokines and chemokines.
Measurement of serum interleukin-6 (IL-6), as a pro-inflammatory cytokine, can be useful in predicting outcome in patients with TBI.
Materials & Methods: In a cross-sectional study, 44 patients with GCS?8 (Glasgow Coma Scale) and age
³ 14 years, hospitalized in Poursina teaching hospital, were included in the study. Blood samples were collected from patients in the first 6 hours after the accident; and serum was tested by ELISA method for the determination of IL-6 levels. Patients' outcomes were recorded 6 months after head injury according to Glasgow Outcome Scale (GOS), and were divided in two good (GOS ?4) and bad (GOS<3) outcome groups. Data were analyzed in SPSS software version18 using the Spearman's rho, independent-t test, Fisher Exact test and Mann-Whitney test.
Results: Comparison of IL-6 serum levels, in the two groups after 6 months of head injury, showed that mean serum levels of IL-6 in good outcome group was lower than bad outcome group (85.2±51.6 vs.162.3±141.1, respectively) (P<0.03).
Conclusion: Elevated serum levels of IL-6 in patients with severe TBI, is associated with poor clinical outcome.

 
Keyword(s): TRAUMATIC BRAIN INJURY, INTERLEUKIN-6, NEUROLOGICAL INFLAMMATION, CLINICAL OUTCOME
 
References: 
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