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Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   JULY-AUGUST 2014 , Volume 21 , Number 3; Page(s) 482 To 492.
 
Paper: 

INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS

 
 
Author(s):  DIVSALAR ADELEH*, BEHROOZI JAVAD, SABOURY ALI AKBAR
 
* DEPARTMENT OF CELL AND MOLECULAR BIOLOGY, FACULTY OF BIOLOGICAL SCIENCES, KHARAZMI UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background: Diabetes is one of the most common endocrine disorders. In this disease due to increased blood glucose levels, protein glycation increases. Protein glycation in diabetes leads to irreparable consequences. The aim of this study was to investigate the synergic effect of Bee venom and aspirin on human hemoglobin glycation in the presence of glucose.
Materials and Methods: In this experimental study, hemoglobin (10 mg/ml) was incubated in the presence and absence of glucose (40 mM), aspirin (2.5 mM) and Bee venom (in different concentrations of 10, 20 and 40 ?g/ml) for 5 weeks. Amount of hemoglobin glycation was evaluated via investigation of changes in soret band, amount of hemoglobin heme degradation and alteration in secondary structure of protein using UV-visible spectroscopy, fluorometry and Circular Dichroism Spectropolarimetry methods. The data were analyzed using In Stat 3 software and statistical tests including one way variance analysis and Turkey test. P values less than 0.05 were considered significant.
Results: Hemoglobin incubation in the presence of glucose led to reduction of soret band absorption, degradation of heme and increment of beta sheet value in secondary structure of hemoglobin. Simultaneous presence of Bee venom and aspirin reduced the rate of heme degradation (p<0.001) up to 36%, and the beta sheet formation up to 54% (p<0.001). Also, the amount of structural alteration and hemoglobin glycation significantly decreased.
Conclusion: Bee venom and aspirin have significant antiglycation properties and simultaneous use of them can decrease protein glycation.

 
Keyword(s): DIABETES, GLYCATION, BEE VENOM, ASPIRIN
 
 
References: 
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Click to Cite.
APA: Copy

DIVSALAR, A., & BEHROOZI, J., & SABOURY, A. (2014). INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 21(3), 482-492. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407506



Vancouver: Copy

DIVSALAR ADELEH, BEHROOZI JAVAD, SABOURY ALI AKBAR. INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES. 2014 [cited 2021May10];21(3):482-492. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407506



IEEE: Copy

DIVSALAR, A., BEHROOZI, J., SABOURY, A., 2014. INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, [online] 21(3), pp.482-492. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407506.



 
 
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