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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   2ND WEEK, FEBRUARY 2014 , Volume 31 , Number 264; Page(s) 2031 To 2041.
 
Paper: 

COMPARING THE INHALABLE AND PARENTERAL FORMS OF ERYTHROPOIETIN IN ENHANCEMENT OF RETICULOCYTES COUNT

 
 
Author(s):  VARSHOSAZ JALEH*, MINAIYAN MOHSEN, SAMI MARYAM
 
* NOVEL DRUG DELIVERY SYSTEMS RESEARCH CENTER, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: In patients with renal failure, frequent use of erythropoietin is necessary for long times due to serious anemia. The aim of the present study was production of an inhalable dry powder of erythropoietin and comparison it with its parenteral form in erythrocytes count enhancement.
Methods: The inhalable powder was prepared using spray-drying of the mixture of poly (methyl-vinyl ether-maleic anhydride), 2-hydroxy propyl-alpha-cyclodextrin and terhalose. The freeze-dried aqueous solution of erythropoietin was mixed with the spray-dried powder in 1: 4 ratio. The particle size and drug content uniformity were determined in the final dried powder. There were 3 groups of rats each containing 6 animals. One group received 840 IU as subcutaneous (sc) injection of regular solution of the drug. The other was treated with blank pulmonary powder and the last group with 840 IU of the spray dried pulmonary powder. Six days before starting the treatment, all animals were fed with 1% (w/w) ferrous sulfate as gavage. Blood sampling was carried out from eye retro-orbital vein at 0, 1, 4 and 7 days after treatment and the reticulocytes were counted by hemocytometer.
Findings: There was not any significant difference between control, inhalable and parenteral groups at days of 0 and 1 after administration. At the day 4, there was significant difference between all three groups and reticulocytes count was higher in the inhalable group than the parenteral (P<0.001) and the control groups (P<0.010). At the 7th day, the results were similar to the 4th day but the reticulocytes count of ininhalable group was significantly higher than the control and parenteral groups (P<0.001 for both).
Conclusion: The spray-dried inhalable powder of erythropoietin was more effective than subcutaneous injection form in enhancing the reticulocytes count for a longer time and may be a good replacement for the parenteral form of this drug.

 
Keyword(s): ERYTHROPOIETIN, RETICULOCYTE, PULMONARY DRUG DELIVERY, CHRONIC RENAL FAILURE
 
 
References: 
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APA: Copy

VARSHOSAZ, J., & MINAIYAN, M., & SAMI, M. (2014). COMPARING THE INHALABLE AND PARENTERAL FORMS OF ERYTHROPOIETIN IN ENHANCEMENT OF RETICULOCYTES COUNT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(264), 2031-2041. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407464



Vancouver: Copy

VARSHOSAZ JALEH, MINAIYAN MOHSEN, SAMI MARYAM. COMPARING THE INHALABLE AND PARENTERAL FORMS OF ERYTHROPOIETIN IN ENHANCEMENT OF RETICULOCYTES COUNT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2014 [cited 2021May11];31(264):2031-2041. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407464



IEEE: Copy

VARSHOSAZ, J., MINAIYAN, M., SAMI, M., 2014. COMPARING THE INHALABLE AND PARENTERAL FORMS OF ERYTHROPOIETIN IN ENHANCEMENT OF RETICULOCYTES COUNT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 31(264), pp.2031-2041. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407464.



 
 
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