Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   1ST WEEK SEPTEMBER 2014 , Volume 32 , Number 292; Page(s) 1 To 7.
 
Paper: 

COMPARISON OF SINGLE-DOSE AND MULTIPLE-DOSE SYSTEMIC METHOTREXATE REGIMEN FOR ECTOPIC PREGNANCY

 
 
Author(s):  FAKHERI TARAVAT, NANKALI ANISODOWLEH, SHAHLAZADEH HALE*, ATAEE MINA, NEYAKAN SHAHRI MINA
 
* DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, EMAM REZA HOSPITAL, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Background: Ectopic pregnancy is a common serious problem with high morbidity percentage and possibility of maternal mortality. We can diagnose ectopic pregnancy earlier than the clinic will be present and this will give us the possibility to apply the best treatment with fewer complications. Quantity b-hCG measure, ultrasound examination inform us for the diagnose of ectopic pregnancy and surgical treatment can be avoided. The treatment will be determined by combination of clinical symptoms, ultrasound examination and b-hCG levels.
Methods: we were treated (Semi-empirical) with systemic methotrexate therapy at the Department of Obstetrics and Gynecology, EMAM REZH Hospital in kermanshah. The patients were treated with either of the two regimens: a) Single dose regimen: 50 mg/m2 of intramuscular MTX (60 cases) b) Multiple dose regimen: 4 doses of 1 mg/kg of IM MTX (60 cases). Serum beta-hCG value at initiation of treatment.
Findings: The overall success rate of MTX management for an ectopic pregnancy was76% for single and multiple dose regimen was 96.7%. THE rupture of EP mass was 3.3% in multiple dose and 10% in single dose during of treatment.
Conclusion: multiple dose of methotrexate therapy is an effective than single dose safe treatment.

 
Keyword(s): ECTOPIC PREGNANCY, METOTROXITE, BHCG
 
References: 
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