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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   1ST WEEK SEPTEMBER 2014 , Volume 32 , Number 292; Page(s) 1 To 8.
 
Paper: 

COMPARISON OF DIFFERENT CLASSIFIERS FOR PREDICTION OF BREAST CANCER METASTASIS IN MICRO ARRAY ANALYSIS

 
 
Author(s):  AMINI ZAHRA, MEHRIDEHNAVI ALIREZA*
 
* DEPARTMENT OF BIOELECTRIC & BIOMEDICAL ENGINEERING, SCHOOL OF ADVANCED MEDICAL TECHNOLOGY, ISFAHAN, UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: In this paper, we investigated the performance of some different classifiers for prediction metastasis in breast cancer.
Methods: For this purpose we used the DNA microarrays of primary breast tumors of 78 young patients. Among these patients, 34 patients had developed distant metastases within 5 years (poor prognosis group) and 44 patients formed good prognosis group. For analysis, we applied three different classifiers include Support Vector Machine (SVM), StepWise Linear Discriminant Analysis (SWLDA) and K-Nearest Neighbors (KNN) classifier. Each of these classifiers used 231 selected genes as an input feature vector and their performance was estimated by using leave one out (LOO) method to classify patients into two groups namely, good and poor prognosis.
Findings: The best results were obtained by SVM with linear kernel. This classifier achieved a sensitivity and specificity of 84% and 82% respectively for metastasis prediction.
Conclusion: Our findings provide a strategy to specify patients who would benefit from adjuvant therapy.

 
Keyword(s): MICROARRAYS, PREDICTION OF BREAST CANCER, SUPPORT VECTOR MACHINE (SVM), STEPWISE LINEAR DISCRIMINANT ANALYSIS (SWLDA) AND K-NEAREST NEIGHBORS (KNN) CLASSIFIERS
 
 
References: 
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Click to Cite.
APA: Copy

AMINI, Z., & MEHRIDEHNAVI, A. (2014). COMPARISON OF DIFFERENT CLASSIFIERS FOR PREDICTION OF BREAST CANCER METASTASIS IN MICRO ARRAY ANALYSIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 32(292), 1-8. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407192



Vancouver: Copy

AMINI ZAHRA, MEHRIDEHNAVI ALIREZA. COMPARISON OF DIFFERENT CLASSIFIERS FOR PREDICTION OF BREAST CANCER METASTASIS IN MICRO ARRAY ANALYSIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2014 [cited 2021May09];32(292):1-8. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407192



IEEE: Copy

AMINI, Z., MEHRIDEHNAVI, A., 2014. COMPARISON OF DIFFERENT CLASSIFIERS FOR PREDICTION OF BREAST CANCER METASTASIS IN MICRO ARRAY ANALYSIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 32(292), pp.1-8. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407192.



 
 
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