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Paper Information

Journal:   JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES   FALL 2014 , Volume 16 , Number 3 (51); Page(s) 31 To 39.
 
Paper: 

PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY

 
 
Author(s):  SOLEIMANI MEHRANJANI M.*, NADERI NOREINI S.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, ARAK UNIVERSITY, ARAK, IRAN
 
Abstract: 

Background and Objective: Para-nonylphen as an environmental pollutant has weak estrogenic activity and causes oxidative stress in different organs including testis. This study was done to determine the protective effect of vitamin E on the para-nonylphenol induced-testicular toxicity in adult rats.
Methods: In this experimental study, 24 Wistar rats were randomly allocated into four groups including control, vitamin E (100 mg/kg/day, orally), para-nonylphenol (250 mg/kg/day, orally) and finally paranonylphenol (250 mg/kg/day, orally) plus vitamin E (100 mg/kg/day, orally). After 56 days of treatment, removal of the right testis, tissue processing and staining with Heidenhain’s Azan, the morphometric parameters of testicular tissue was evaluated using stereological method.
Results: The mean volume of seminiferous tubules, height of the germinal epithelium, seminiferous tubules diameter, thickness of the basement membrane, number of spermatocyte, spermatid and sertoli cells significantly reduced in para-nonylphenol group compared to the controls (P
<0.05). These parameters were significantly increased in the para-nonylphenol plus vitamin E group compared to para-nonylphenol group (P<0.05). In the histopathological examination, atrophy of seminiferous tubules, germinal epithelium vacuolation and epithelial disarrangement were observed in para-nonylphenol group. Histopathological alterations reduced in para-nonylphenol plus vitamin E group compared to para-nonylphenol group.
Conclusion: Co-administration of vitamin E with para-nonylphenol can prevent the adverse effects of para-nonylphenol on the testicular tissue in adult rats.

 
Keyword(s): TESTIS, SEMINIFEROUS TUBULE, PARA-NONYLPHENOL, VITAMIN E, STEREOLOGY, RAT
 
 
References: 
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Citations: 
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APA: Copy

SOLEIMANI MEHRANJANI, M., & NADERI NOREINI, S. (2014). PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(3 (51)), 31-39. https://www.sid.ir/en/journal/ViewPaper.aspx?id=406977



Vancouver: Copy

SOLEIMANI MEHRANJANI M., NADERI NOREINI S.. PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES. 2014 [cited 2021November28];16(3 (51)):31-39. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=406977



IEEE: Copy

SOLEIMANI MEHRANJANI, M., NADERI NOREINI, S., 2014. PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, [online] 16(3 (51)), pp.31-39. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=406977.



 
 
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