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Paper Information

Journal:   JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES   FALL 2014 , Volume 16 , Number 3 (51); Page(s) 16 To 23.
 
Paper: 

EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE

 
 
Author(s):  JAFARZADEH H., ARABI M., NAJAFI N.*, AHADI A.M.
 
* DEPARTMENT OF BIOLOGY, SHAHREKORD UNIVERSITY, SHAHREKORD, IRAN
 
Abstract: 

Background and Objective: Aloe vera (Aloe barbadensis M.) as a medicinal herb is practiced in wound healing. This study was carried out to assess the effect of Aloe vera gel (mucilage) on TGF-b gene expression in incisional skin wound in BALB/c mice.
Method: In this experimental study, 36 BALB/c male mice with weight range 22
±2 gr were allocated equally into negative control (no wound), sham-operated (wound treated with physiological serum) and teratment (wound treated with Aloe vera gel). Two equal full-thickness skin wounds of 10±2mm were made on either side of the vertebral column in the sacral region. The animals in the teratment group were received daily, 2 gram of Aloe vera gel (without any bandage) as a thin layer for a period of 16 days. On 8th and 16th post wounding day, TGF-b gene expression in incisional wounds and Malonyldialdehyde (as end-product of lipid peroxidation) in serum samples was measured using RT-PCR and spectrophotometry methods, respectively.
Results: TGF-
b gene expression in incisional skin wound increased in Aloe vera gel treated group in compared to negative control and sham-operated groups (P<0.05). Malonyldialdehyde concentration was significantly reduced in Aloe vera treated group in comparision with negative control and sham-operated groups.
Conclusion: Aloe vera gel can induce growth factor TGF-
b gene expression and reducing the lipid peroxidation content can play an important role in incisional skin wound healing process.

 
Keyword(s): SKIN, INCISIONAL WOUND, ALOE VERA, TGF-β GENE, MALONYLDIALDEHYDE, MOUSE
 
 
References: 
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Click to Cite.
APA: Copy

JAFARZADEH, H., & ARABI, M., & NAJAFI, N., & AHADI, A. (2014). EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(3 (51)), 16-23. https://www.sid.ir/en/journal/ViewPaper.aspx?id=406953



Vancouver: Copy

JAFARZADEH H., ARABI M., NAJAFI N., AHADI A.M.. EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES. 2014 [cited 2021May14];16(3 (51)):16-23. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=406953



IEEE: Copy

JAFARZADEH, H., ARABI, M., NAJAFI, N., AHADI, A., 2014. EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, [online] 16(3 (51)), pp.16-23. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=406953.



 
 
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