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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   APRIL 2014 , Volume 17 , Number 4; Page(s) 250 To 255.
 
Paper: 

NUMERICAL STATUS OF CD4+CD25+FOXP3+ AND CD8+CD28- REGULATORY T CELLS IN MULTIPLE SCLEROSIS

 
 
Author(s):  KOUCHAKI EBRAHIM, SALEHI MAHDI, SHARIF MOHAMMAD REZA, NIKOUEINEJAD HASSAN*, AKBARI HOSSEIN
 
* NEPHROLOGY AND UROLOGY RESEARCH CENTER, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective (s): Regulatory T cells, including CD4+CD25+Fox3+and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells and also their association with different clinical characteristics in 84 multiple sclerosis patients.
Materials and Methods: 84 patients with multiple sclerosis and 75 normal individuals were studied. Demographic and clinical information of all participants were collected via questionnaire and clinical examination as well as MRI. The peripheral blood frequency of two different subgroups of regulatory T cells (CD4+CD25+Foxp3+and CD8+CD28- cells) were analyzed by flow cytometry using anti-human antibodies conjugated with CD4-FITC/ CD25-PE/Foxp3-PE-Cy5, CD3-PE/CD8a-PE-Cy5/CD28-FITC.
Results: The frequency of CD4+CD25+Foxp3+cells in multiple sclerosis patients was significantly less than that in healthy controls (P=0.006) and in mild forms less than that in sever forms (P=0.003). There was not any correlation between the frequency of regulatory T cells and different clinical variables.
Conclusion: Our results showed that the number of CD4+CD25+Foxp3+cells decreases significantly in multiple sclerosis patients, which probably shows the regulatory role of these cells in multiple sclerosis.

 
Keyword(s): CD4+CD25+FOXP3+-, REGULATORY T CELLS, CD8+CD28- REGULATORY T CELLS, MULTIPLE SCLEROSIS
 
 
References: 
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Click to Cite.
APA: Copy

KOUCHAKI, E., & SALEHI, M., & SHARIF, M., & NIKOUEINEJAD, H., & AKBARI, H. (2014). NUMERICAL STATUS OF CD4+CD25+FOXP3+ AND CD8+CD28- REGULATORY T CELLS IN MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(4), 250-255. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405816



Vancouver: Copy

KOUCHAKI EBRAHIM, SALEHI MAHDI, SHARIF MOHAMMAD REZA, NIKOUEINEJAD HASSAN, AKBARI HOSSEIN. NUMERICAL STATUS OF CD4+CD25+FOXP3+ AND CD8+CD28- REGULATORY T CELLS IN MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May12];17(4):250-255. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405816



IEEE: Copy

KOUCHAKI, E., SALEHI, M., SHARIF, M., NIKOUEINEJAD, H., AKBARI, H., 2014. NUMERICAL STATUS OF CD4+CD25+FOXP3+ AND CD8+CD28- REGULATORY T CELLS IN MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(4), pp.250-255. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405816.



 
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