Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2013 , Volume 7 , Number SUPPLEMENT 1; Page(s) 114 To 115.
 
Paper: 

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS IN ENDOMETRIOSIS

 
 
Author(s):  NOORI E.*, NASRI S., JANAN A., MOHEBBI A., MOINI A., RAMAZANALI F., LAKPOUR M.R., AFLATOONIAN R.
 
* DEPARTMENT OF BIOLOGY, PAYAM NOOR UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background: Endometriosis is a disease which is defined by the growth of endometrium-like tissue outside of the uterine cavity. Literatures show that VEGF by interaction with their receptors, Flt-1 (Fms-like tyrosine kinase-1 or VEGFR-1) and Flk-1/KDR (fetal liver kinase/ kinase-insert domain receptor or VEGFR-2) is related to pathogenesis of endometriosis. The purpose of this study was to evaluate the expression of VEGF receptors and also their relationship with development and survival of endometriotic lesions in the endometriosis throughout the menstrual cycle.
Materials and Methods: This study contain three groups (n=30). In patients with endometriosis, ectopic (ovarian endometrioma) and eutopic biopsies were obtained by laparoscopic procedure and piplle respectively. In women with no sign of endometriosis, control biopsies gained with piplle. The samples in each group were obtained in different stages of the menstrual cycle. Gene expression of VEGF was determined by RT-PCR and the quantitative level of gene expression was tested by Real Time PCR.
Results: VEGF receptors were expressed in all groups.
In eutopic endometrium from women without endometriosis, the expression of VEGFR1 and VEGFR2 were significantly higher during the menstruation than the secretory and proliferative phases. However, a significant increasing were observed in VEGFR1 level in secretory phase as well as VEGFR2 level in proliferative phase in eutopic endometrium from women with endometriosis (p<0.05).
Conclusion: It seems that different regulation of VEGF receptors in pathological condition depends on the site of endometriosis. Our data showed that ovarian endometriomas are lesions with low angiogenic activity and low ability of remodeling the surrounding tissue.

 
Keyword(s): ANGIOGENESIS, ENDOMETRIOSIS, VEGF RECEPTORS
 
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