Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   DECEMBER 2013 , Volume 16 , Number 12; Page(s) 1270 To 1275.
 
Paper: 

8-OH-DPAT (5-HT1A AGONIST) ATTENUATES 6-HYDROXY-DOPAMINE-INDUCED CATALEPSY AND MODULATES INFLAMMATORY CYTOKINES IN RATS

 
 
Author(s):  SHARIFI HAMDOLAH, MOHAJJEL NAYEBI ALIREZA*, FARAJNIA SAFAR
 
* DRUG APPLIED R ESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Objective (s): Neuroinflammation in Parkinson disease (PD) is associated with glial cells activation and production of different inflammatory cytokines. In this study, we investigated the effect of chronic administration of 8-OH-DPAT on 6-OHDA-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (CSF).
Materials and Methods: Catalepsy was induced by unilateral infusion of 6-OHDA (8
mg/2 ml/rat) into the central region of the sabstantia nigra pars compacta (SNc) being assessed by the bar-test, 5, 60, 120 and 180 min after intraperitoneal (IP) administration of 8-OH-DPAT (5-HT1A receptor agonist; 0.25, 0.5 and 1mg/kg, IP for 10 days). CSF samples were collected on the tenth day of 8-OH-DPAT administration and analyzed by ELISA method to measure levels of TNF-a, IL-1b and IL-6.
Results: Chronic injection of 8-OH-DPAT decreased catalepsy in a dose dependent manner when compared with the control group. The most anti-cataleptic effect was observed at the dose of 1 mg/kg of 8-OH-DPAT. Levels of TNF-
a in CSF increased three weeks after 6-OHDA injection while there was a significant decrease in TNF-a level of parkinsonian animals treated with 8-OH-DPAT (1 mg/kg, IP for 10 days). IL-1 b and IL-6 decreased and increased in parkinsonian rats and in 8-OH-DPAT-treated parkinsonian rats, respectively.
Conclusion: Our study indicated that chronic administration of 8-OH-DPAT improves catalepsy in 6- OHDA-induced animal model of PD and restores central concentration of inflammatory cytokines to the basal levels.5-HT1A receptor agonists can be suggested as potential adjuvant therapy in PD by modulation of cerebral inflammatory cytokines.

 
Keyword(s): 8-OH-DPAT CATALEPSY CHRONIC CYTOKINES RAT
 
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