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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   DECEMBER 2013 , Volume 16 , Number 12; Page(s) 1232 To 1237.
 
Paper: 

EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY

 
 
Author(s):  BOSKABADI HASSAN, MAAMOURI GHOLAMALI, TAVAKOL AFSHARI JALIL, MAFINEJAD SHAHIN, HOSSEINI GOLKOO, MOSTAFAVI TOROGHI HESAM, SABER HAMIDREZA, GHAYOUR MOBARHAN MAJID*, FERNS GORDON
 
* BIOCHEMISTRY OF NUTRITION RESEARCH CENTER, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective (s): Bacterial infection contributes substantially to neonatal morbidity and mortality. Early diagnosis of neonatal sepsis is difficult because clinical signs are non-specific. We have evaluated serum IL-6, 8 and 10 as potential early diagnostic markers of neonatal infection and their relationship to mortality rate and poor prognosis.
Materials and Methods: A total of 84 infants, aged ? 72 hr were enrolled in this prospective case-control trial. The case group (n=41) included babies with clinical and laboratory findings compatible with sepsis and/or positive blood or cerebrospinal fluid cultures. The control group (n=43) included healthy infants. IL-6, 8 and 10 were measured for all infants. Receiver-operating characteristic (ROC) curves were used for the determination of thresholds.
Results: Statistically significant differences were observed between control and case groups for serum median level of IL-6, 8 and 10 (P<0.001). IL-6 cut-off values of 10.85 Pg/ml for discriminating between cases and controls and 78.2 Pg/ml for predicting mortality are suggested. IL-8 at a cut-off value of 60.05 Pg/ml was valuable for differentiation of definite versus indefinite infection.
Conclusion: Evaluating the IL-6, 8 and 10 simultaneously, could improve the sensitivity and specificity of early diagnosis of the neonatal sepsis. Regarding our results, interleukin 6 had the greatest value for predicting infection and possible mortality, whereas IL-8 was valuable for diagnosing definitive infection.

 
Keyword(s): INFECTION, INTERLEUKIN-6, INTERLEUKIN-8, INTERLEUKIN-10, NEWBORN, SEPSIS
 
 
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APA: Copy

BOSKABADI, H., & MAAMOURI, G., & TAVAKOL AFSHARI, J., & MAFINEJAD, S., & HOSSEINI, G., & MOSTAFAVI TOROGHI, H., & SABER, H., & GHAYOUR MOBARHAN, M., & FERNS, G. (2013). EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1232-1237. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405645



Vancouver: Copy

BOSKABADI HASSAN, MAAMOURI GHOLAMALI, TAVAKOL AFSHARI JALIL, MAFINEJAD SHAHIN, HOSSEINI GOLKOO, MOSTAFAVI TOROGHI HESAM, SABER HAMIDREZA, GHAYOUR MOBARHAN MAJID, FERNS GORDON. EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May18];16(12):1232-1237. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405645



IEEE: Copy

BOSKABADI, H., MAAMOURI, G., TAVAKOL AFSHARI, J., MAFINEJAD, S., HOSSEINI, G., MOSTAFAVI TOROGHI, H., SABER, H., GHAYOUR MOBARHAN, M., FERNS, G., 2013. EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(12), pp.1232-1237. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405645.



 
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