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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   DECEMBER 2013 , Volume 16 , Number 12; Page(s) 1209 To 1216.
 
Paper: 

COMBINATION ANTIOXIDANT EFFECT OF ERYTHROPOIETIN AND MELATONIN ON RENAL ISCHEMIA-REPERFUSION INJURY IN RATS

 
 
Author(s):  AHMADIASL NASSER, BANAEI SHOKOFEH*, ALIHEMMATI ALIREZA
 
* DEPARTMENT OF PHYSIOLOGY, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Objective (s): Renal ischemia reperfusion (IR) contributes to the development of acute renal failure (ARF). Oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal IR. The purpose of this study was to investigate the effect of co-administration of melatonin (MEL) and erythropoietin (EPO), potent antioxidant and anti-inflammatory agents, on IR-induced renal injury in rats.
Materials and Methods: Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 hr reperfusion. MEL (10 mg/kg, IP) and EPO (5000 U/kg, IP) were administered prior to ischemia. After 24 hr reperfusion, following decapitation, renal samples were taken for the determination of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) levels and histological evaluation. The level of urea was measured in serum samples.
Results: Ischemia reperfusion significantly increased urea, and MDA levels, and decreased CAT and SOD activities. Histopathological findings of the IR group confirmed that there was renal impairment in the tubular epithelium. Treatment with EPO and MEL markedly decreased urea level and increased SOD and GPx activities.
Conclusion: Treatment with EPO and MEL had a beneficial effect on renal IR injury. These results may show that the co-administration of MEL and EPO cannot exert more beneficial effects than either agent alone.

 
Keyword(s): ANTIOXIDANT ERYTHROPOIETIN ISCHEMIA REPERFUSION INJURY KIDNEY LIPID PEROXIDATION MELATONIN
 
 
References: 
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Click to Cite.
APA: Copy

AHMADIASL, N., & BANAEI, S., & ALIHEMMATI, A. (2013). COMBINATION ANTIOXIDANT EFFECT OF ERYTHROPOIETIN AND MELATONIN ON RENAL ISCHEMIA-REPERFUSION INJURY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1209-1216. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405628



Vancouver: Copy

AHMADIASL NASSER, BANAEI SHOKOFEH, ALIHEMMATI ALIREZA. COMBINATION ANTIOXIDANT EFFECT OF ERYTHROPOIETIN AND MELATONIN ON RENAL ISCHEMIA-REPERFUSION INJURY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May11];16(12):1209-1216. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405628



IEEE: Copy

AHMADIASL, N., BANAEI, S., ALIHEMMATI, A., 2013. COMBINATION ANTIOXIDANT EFFECT OF ERYTHROPOIETIN AND MELATONIN ON RENAL ISCHEMIA-REPERFUSION INJURY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(12), pp.1209-1216. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405628.



 
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