Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2013 , Volume 7 , Number SUPPLEMENT 1; Page(s) 110 To 111.
 
Paper: 

EFFECT OF NALOXONE ON ENDOMETRIAL GROWTH

 
 
Author(s):  LAKZAEI F.*, KARAMI M., JALALI NADOUSHAN M.R., HASSANI F.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, SHAHED UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background: There is fine correlation between the infertility and lessening of endometrial thickness. In this study the effects of sedative naloxone, and L-arginine, the precursor of nitric oxide (NO), on endometrial thickness of rat uterus was examined.
Materials and Methods: Wistar rats (weighing 200-250 g) in Diestrous phase received intra-peritoneal (i.p.) 1. single L-arginine (50 mg/kg), 2. single naloxone (0.4 mg/ kg) and 3. naloxone (0.4 mg/kg) 30 minutes priorly to the L-arginine (50 mg/kg) during 9 days/ once a day. The control group exclusively received saline (1 ml/kg, i.p.) throughout the treatment period. After completion of the treatments, all rats were coupled with intact males and after observation of vaginal plaques they were isolated and graded 0 of gestation. The females were subsequently passed surgical examination in days 19-20 of gestation.
Results: Based on the findings the group that only administered L-arginine, nevertheless of endometrial development, showed low pregnancy and fetal count to control. However, naloxone pre-treatment caused significant raise in the rates. The rate, furthermore, showed an increase in single naloxone group.
Conclusion: Endometrial wideness may occur due to angiogenesis and expansion of blood flow in the endometrial wall and by growing of the wall glands and matrix. The L-arginine may produce the NO, a putative increasing factor of blood flow. This factor, however, is not as effective as do in the presence of naloxone. The naloxone can develop the endometrial growth in Wistar rat.

 
Keyword(s): NALOXONE, L-ARGININE, ENDOMETRIAL THICKNESS
 
References: 
  • ندارد
 
  Yearly Visit 37
 
Latest on Blog
Enter SID Blog