Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MARCH 2014 , Volume 17 , Number 3; Page(s) 216 To 219.
 
Paper: 

PLASMA LEVELS OF INTERLUKIN-4 AND INTERFERON-γ IN PATIENTS WITH CHRONIC OR HEALED CUTANEOUS LEISHMANIASIS

 
 
Author(s):  TAHERI AHMAD REZA, MASHAYEKHI GOYONLO VAHID, NAHIDI YALDA, MOHEGHI NASRIN, TAVAKKOL AFSHARI JALIL*
 
* IMMUNOLOGY RESEARCH CENTER, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective (s): In this study, the serum level of interferon-g (IFN-g) and interlukin-4 (IL-4) was evaluated as a marker of Th1 and Th2 immune response that influence the clinical course of cutaneous leishmaniasis.
Materials and Methods: This cross-sectional study was conducted on 44 cases of cutaneous leishmaniasis (21 cases with healed lesions and 23 cases with chronic non-healing lesions. Thirty-two non-infected persons living in the area were considered as controls. Serum levels of IFN-
g and IL-4 were determined using ELISA, and the results along with clinical data were analyzed using SPSS 11.5.
Results: Serum IFN-
g level was not significantly different between various patient groups and control (P=0.27), but the serum level of IL-4 in patient groups was higher than in healthy subjects, and it was higher in patients with non-healed chronic cutaneous leishmaniasis than those with healed lesions (P<0.01).
Conclusion: Serum IL-4 level is a good marker for evaluation of the clinical course of cutaneous leishmaniasis.

 
Keyword(s): CUTANEOUS LEISHMANIASIS, INTERFERON-γ, INTERLUKIN-4, T HELPER CELL
 
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