Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2014 , Volume 17 , Number 5; Page(s) 384 To 390.
 
Paper: 

TESTICULAR MORPHOLOGY OF MALE RATS EXPOSED TO PHALERIA MACROCARPA (MAHKOTA DEWA) AQUEOUS EXTRACT

 
Author(s):  PARHIZKAR SAADAT, ZULKIFLI SURIANI BINTI, DOLLAH MOHAMMAD AZIZ*
 
* IOMEDICAL DEPARTMENT, FACULTY OF MEDICINE AND HEALTH SCIENCES, UNIVERSITY PUTRA MALAYSIA, 43400 SERDANG, SELANGOR, DARUL EHSAN, MALAYSIA
 
Abstract: 

Objective (s): This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats.
Materials and Methods: PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. Eighteen Sprague Dawley adult male rats were divided into three groups (six in each group), designated as treatment (240 mg/kg PM), negative control (distilled water) and positive control (4mg/kg testosterone) and administered via intragastric gavage for seven weeks. In the sixth week of supplementation period, each male rat was introduced to five female rats. Afterward, all rats were sacrificed and the testes were removed for histological studies.
Results: PM significantly increased the number of cell and the thickness of seminiferous tubules of male rats (P<0.05). However, there was no significant effect on the volume and size of testes. The mean of spermatogonia cells numbers of PM groups differed significantly from the negative and positive groups (P<0.05).
Conclusion: PM showed potential value as an attractive alternative for improving sexual strength by increasing the number of spermatogonia cell and the thickness of the seminiferous tubules. Perhaps, PM could be suggested to be one of the herbal remedies that can improve men fertility. The results may have some clinical implication in the management of infertility.

 
Keyword(s): HERBAL MEDICINE, INFERTILITY, PHALERIA MACROCARPA, SEMINIFEROUS TUBULES, SPERMATOGENESIS
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 48
 
Latest on Blog
Enter SID Blog