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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2014 , Volume 17 , Number 5; Page(s) 391 To 395.
 
Paper: 

EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN

 
 
Author(s):  MOHAMMADI KARAKANI ALI, ASGHARZADEH HAGHIGHI SOLMAZ, GHAZI KHANSARI MAHMOUD*, SEYED EBRAHIMI AFSANEH, ZEIGHAMI MOHAMMADI SHARAREH
 
* DEPARTMENTS OF PHARMACOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective (s): In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-b-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated with gentamicin.
Materials and Methods: Fourteen pre-term and fifteen full-term newborns who received gentamicin for suspected infections were enrolled. Serum and urine specimens were obtained before the zero days and after gentamicin infusion on the 1st, 3rd, and 5th days of treatment.
Results: In full-term newborns a significant increase in urinary NAG, LDH, AP after 5 days of gentamicin administration compared with control group was noted (P<0.05, P<0.001 and P<0.01; respectively).
Conclusion: Our findings indicate that urinary enzymes may be useful in full-term newborns as a non-invasive method for evaluation of tubular function.

 
Keyword(s): BIOMARKER, GENTAMICIN, NEWBORN, URINE
 
 
References: 
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Click to Cite.
APA: Copy

MOHAMMADI KARAKANI, A., & ASGHARZADEH HAGHIGHI, S., & GHAZI KHANSARI, M., & SEYED EBRAHIMI, A., & ZEIGHAMI MOHAMMADI, S. (2014). EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(5), 391-395. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405594



Vancouver: Copy

MOHAMMADI KARAKANI ALI, ASGHARZADEH HAGHIGHI SOLMAZ, GHAZI KHANSARI MAHMOUD, SEYED EBRAHIMI AFSANEH, ZEIGHAMI MOHAMMADI SHARAREH. EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May11];17(5):391-395. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405594



IEEE: Copy

MOHAMMADI KARAKANI, A., ASGHARZADEH HAGHIGHI, S., GHAZI KHANSARI, M., SEYED EBRAHIMI, A., ZEIGHAMI MOHAMMADI, S., 2014. EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(5), pp.391-395. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405594.



 
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