Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY 2013 , Volume 16 , Number 7; Page(s) 850 To 858.
 
Paper: 

EVALUATION OF THE EFFECTS OF CAFFEIC ACID PHENETHYL ESTER ON PROSTAGLANDIN E2 AND TWO KEY CYTOKINES INVOLVED IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS

 
 
Author(s):  LARKI HARCHEGANI AMIR, HEMMATI ALI ASGHAR*, ARZI ARDESHIR, GHAFOURIAN BOROOJERDNIA MEHRI, SHABIB SOMAYEH, ZADKARAMI MOHAMMAD REZA, ESMAEILZADEH SALEH
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, SCHOOL OF PHARMACY AND PHYSIOLOGY RESEARCH CENTER, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Objective (s): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an active component of propolis, has numerous biological effects. In the present study, the main objective was to investigate the effects of CAPE on some key mediators including TGF-b1, TNF-a and prostaglandin E 2 (PGE2) involved in profibrotic/ antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (IPF).
Materials and Methods: In this study, forty male Sprague- Dawley rats were divided into 5 groups (n=8). (1) “Bleomycin (BLM) -treated (Model) group”: BLM (5 mg/kg, single intratracheal dose), (2) “Saline-treated group”: the rats were given only saline, (3) “Treatment-1 group”: BLM+CAPE (5
mmol/kg/day, 28 days, IP), (4) “Treatment-2 group”: BLM+CAPE (10 mmol/kg/day, 28 days, IP) and (5) “Vehicle+CAPE group”: CAPE (10 mmol/kg/day, 28 days, IP).
Results: BLM could significantly increase the levels of TNF-? and TGF-? 1 and decrease the PGE 2 concentration compared to the saline control group. CAPE could considerably improve these values almost close to normal levels.
Conclusion: Briefly, CAPE can be suggested as a novel, attractive and effective agent for prevention and treatment of pulmonary fibrosis.

 
Keyword(s): BLEOMYCIN, CAPE, CYTOKINE, PULMONARY FIBROSIS, PGE2, TGF-β1, TNF-α
 
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