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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2013 , Volume 16 , Number 6; Page(s) 743 To 750.
 
Paper: 

RELATIONSHIP OF DOPAMINE OF THE NUCLEUS ACCUMBENS WITH INTRA-INFRALIMBIC APOMORPHINE MICROINJECTION

 
 
Author(s):  ALIMORADIAN ABBAS, SAJEDIANFARD JAVAD*, BAHA ALDINI BEIGY FAEGHEH, PANJEHSHAHIN MOHAMMAD REZA, OWJI ALI AKBARE
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF VETERINARY MEDICINE, SHIRAZ UNIVERSITY, SHIRAZ, IRAN
 
Abstract: 

Objective(s): The dopamine level of the nucleus accumbens changes during some stereotyped behaviors. To study dopamine level of the nucleus accumbens in intra infralimbic apomorphine-induced climbing, microdialysis probes were implanted into the nucleus accumbens shell of male Sprague Dawley rats weighting 275–400 g.
Materials and Methods: The rats were divided into two groups (apomorphine and control) of least eleven rats in each group. Apomorphine at dose of 5
mg/0.5 ml or its vehicle was microinjected into the infralimbic in apomorphine and control groups respectively. Then, changes in dopamine levels in the nucleus accumbens shell were monitored. The concentration of dopamine was measured by High-Performance Liquid Chromatography-Electochemical (HPLC-ECD). Finally, the stereotyped behaviors were recorded.
Results: The mean of dopamine levels for all of after microinjection period in control and drug groups were 450% and 150% respectively compared to those of before microinjection period. However, there was no significant difference between groups of apomorphine and control. In addition, the return of dopamine level to the baseline was faster in apomorphine group than the control group.
Conclusion: The intra infralimbic apomorphine -induced climbing at dose of 5
mg/0.5 ml was not modulated via the increase of dopamine level in the nucleus accumbens area.

 
Keyword(s): APOMORPHINE, DOPAMINE, MICRODIALYSIS, THE NUCLEUS ACCUMBENS, THE PREFRONTAL CORTEX
 
 
References: 
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+ Click to Cite.
APA: Copy

ALIMORADIAN, A., & SAJEDIANFARD, J., & BAHA ALDINI BEIGY, F., & PANJEHSHAHIN, M., & OWJI, A. (2013). RELATIONSHIP OF DOPAMINE OF THE NUCLEUS ACCUMBENS WITH INTRA-INFRALIMBIC APOMORPHINE MICROINJECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(6), 743-750. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405579



Vancouver: Copy

ALIMORADIAN ABBAS, SAJEDIANFARD JAVAD, BAHA ALDINI BEIGY FAEGHEH, PANJEHSHAHIN MOHAMMAD REZA, OWJI ALI AKBARE. RELATIONSHIP OF DOPAMINE OF THE NUCLEUS ACCUMBENS WITH INTRA-INFRALIMBIC APOMORPHINE MICROINJECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May18];16(6):743-750. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405579



IEEE: Copy

ALIMORADIAN, A., SAJEDIANFARD, J., BAHA ALDINI BEIGY, F., PANJEHSHAHIN, M., OWJI, A., 2013. RELATIONSHIP OF DOPAMINE OF THE NUCLEUS ACCUMBENS WITH INTRA-INFRALIMBIC APOMORPHINE MICROINJECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(6), pp.743-750. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405579.



 
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