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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2014 , Volume 17 , Number 5; Page(s) 370 To 377.
 
Paper: 

MUTATIONS IN PRE-CORE AND BASAL-CORE PROMOTER REGIONS OF HEPATITIS B VIRUS IN CHRONIC HBV PATIENTS FROM GOLESTAN, IRAN

 
 
Author(s):  MORADI ABDOLVAHAB, ZHAND SAREH, GHAEMI AMIR, JAVID NAEME, BAZOURI MASOUD, TABARRAEI ALIJAN*
 
* INFECTIOUS DISEASES RESEARCH CENTER, DEPARTMENT OF MICROBIOLOGY, SCHOOL OF MEDICINE, GOLESTAN UNIVERSITY OF MEDICAL SCIENCES, GORGAN, IRAN
 
Abstract: 

Objective (s): It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC). In this study the PC and BCP mutations were investigated in chronic HBV patients.
Materials and Methods: In this study, 120 chronic HBV patients from Golestan, Northeast of Iran who were not vaccinated against HBV, were recruited from the year 2008 to 2012. HBV-DNA extraction from plasma and PCR were performed and positive PCR products were subjected to automated sequencing.
Results: One hundred out of 120 (83.3%) patients were HBeAg negative. Comparison of our nucleotide sequences with reference sequence showed high rate mutation in BCP and PC region (96.66%). Frame shift mutation was found in 78 (65%) of patients in BCP region, among them 8 (6.6%) patients showed mutation in PC region.
Conclusion: Our results demonstrated high rate of mutations in BCP and PC regions among HBV chronic patients in Northeast of Iran.

 
Keyword(s): BCP MUTATION, HEPATITIS B, IRAN, PC MUTATION
 
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