Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   OCTOBER 2013 , Volume 16 , Number 10; Page(s) 1100 To 1108.
 
Paper: 

IMPROVEMENT OF PHYSICO-MECHANICAL PROPERTIES OF PARTIALLY AMORPHOUS ACETAMINOPHEN DEVELOPED FROM HYDROALCOHOLIC SOLUTION USING SPRAY DRYING TECHNIQUE

 
 
Author(s):  SADEGHI FATEMEH, TORABI MANSOUR, KHATTAB MOSTAFA, HOMAYOUNI ALIREZA, AFRASIABI GAREKANI HADI*
 
* SCHOOL OF PHARMACY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective (s): This study was performed aiming to investigate the effect of particle engineering via spray drying of hydroalcoholic solution on solid states and physico-mechanical properties of acetaminophen.
Materials and Methods: Spray drying of hydroalcoholic solution (25% v/v ethanol/water) of acetaminophen (5% w/v) in the presence of small amounts of polyninylpyrrolidone K30 (PVP) (0, 1.25, 2.5 and 5% w/w based on acetaminophen weight) was carried out. The properties of spray dried particles namely morphology, surface characteristics, particle size, crystallinity, dissolution rate and compactibility were evaluated.
Results: Spray drying process significantly changed the morphology of acetaminophen crystals from acicular (rod shape) to spherical microparticle. Differential scanning calorimetery (DSC) and x-ray powder diffraction (XRPD) studies ruled out any polymorphism in spray dried samples, however, a major reduction in crystallinity up to 65%, especially for those containing 5% w/w PVP was observed. Spray dried acetaminophen particles especially those obtained in the presence of PVP exhibited an obvious improvement of the dissolution and compaction properties. Tablets produced from spray dried samples exhibited excellent crushing strengths and no tendency to cap.
Conclusions: The findings of this study revealed that spray drying of acetaminophen from hydroalcoholic solution in the presence of small amount of PVP produced partially amorphous particles with improved dissolution and excellent compaction properties.

 
Keyword(s): ACETAMINOPHEN, AMORPHOUS PARTICLES, COMPACTION, CRYSTALLINITY, DISSOLUTION, SPRAY DRYING
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 240
 
Latest on Blog
Enter SID Blog