Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY 2013 , Volume 16 , Number 7; Page(s) 887 To 890.
 
Paper: 

COMPARISON AND EVALUATION OF CURRENT ANIMAL MODELS FOR PERINEURAL SCAR FORMATION IN RAT

 
 
Author(s):  O ZANJANI LEILA, FIROUZI MASOUMEH*, NABIAN MOHAMMAD HOSSEIN, NATEGH MOHSEN, RAHIMI MOVAGHAR VAFA, S KAMRANI REZA
 
* TISSUE REPAIR LAB, INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS, UNIVERSITY OF TEHRAN, ENQELAB ST., TEHRAN, IRAN
 
Abstract: 

Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation around the sciatic nerve of rat: laceration, crush, mince and burn.
Materials and Methods: Functional (Toe out angle), macroscopic, and microscopic evaluations were performed weekly for four weeks and correlation of findings were analyzed.
Result: While macroscopic and microscopic findings suggested a well-developed and adhesive fibrosis surrounding the sciatic nerve, functional assessment did not reveal any significant difference between control and experimental groups (P>0.05).
Conclusion: Our study suggests that none of the applied animal models reproduce all essential features of clinical perineural scar formation. Therefore, more studies are needed to develop optimal animal models for translating preclinical investigations.

 
Keyword(s): SCAR, SCIATIC NERVE, TRANSLATIONAL RESEARCH
 
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