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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2014 , Volume 17 , Number 5; Page(s) 337 To 343.
 
Paper: 

EVALUATION OF SYNTHETIC ZEOLITES AS ORAL DELIVERY VEHICLE FOR ANTI-INFLAMMATORY DRUGS

 
 
Author(s):  KHODAVERDI ELHAM, HONARMANDI REZA, ALIBOLANDI MONA, RAFATPANAH BAYGI ROXANA, HADIZADEH FARZIN*, ZOHURI GHOLAMHOSSEIN
 
* BIOTECHNOLOGY RESEARCH CENTER, MASHHAD UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Objective (s): In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen.
Materials and Methods: A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric methods and IR spectra of prepared formulations were used to assess drug loading efficiencies into zeolite structures. Scanning Electron Microscopy (SEM) was also utilized to determine morphologies changes in synthetic zeolites after drug loading. At the next stage, dissolution studies were used to predict the in vivo performance of prepared formulations at HCl 0.1 N and PBS pH 6.5 as simulated gastric fluid (SGF) and simulated intestine fluid (SIF), respectively.
Results: Drug loadings of prepared formulations was determined between 24-26% w/w. Dissolution tests at SGF were shown that zeolites could retain acidic model drugs in their porous structures and can be able to limit their release into the stomach. On the other hand, all prepared formulations completely released model drugs during 3 hr in simulated intestine fluid.
Conclusion: Obtained results indicated zeolites could potentially be able to release indomethacin and ibuprofen in a sustained and controlled manner and reduced adverse effects commonly accompanying oral administrations of NSAIDs.

 
Keyword(s): CONTROLLED DRUG DELIVERY-SYSTEMS, IBUPROFEN, INDOMETHACIN, ZEOLITE
 
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