Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   OCTOBER 2013 , Volume 16 , Number 10; Page(s) 1109 To 1113.
 
Paper: 

STUDY THE ANTINOCICEPTIVE EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF AQUEOUS EXTRACT OF ORIGANUM VULGARE LEAVES IN RAT: POSSIBLE INVOLVEMENT OF OPIOID SYSTEM

 
 
Author(s):  PAHLAVAN YASAMAN, SEPEHRI GHOLAMREZA*, SHEIBANI VAHID, AFARINESHE KHAKI MOHAMMAD REZA, GOJAZADEH MORTEZA, PAHLAVAN BAHARE, PAHLAVAN FERESHTEH
 
* NEUROSCIENCE RESEARCH CENTER AND DEPARTMENT OF PHYSIOLOGY, FACULTY OF MEDICINE, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Objective (s): The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors.
Materials and Methods: Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6
mg / rat). Effective dose of ORG was injected ICV in concomitant with morphine (2 mg/kg, IP), naloxone (2 mg / kg, IP) and saline (0.5 ml/rat) and TFL was recorded.
Results: The co- administration of ORG extract with morphine showed a significant increase in TFL and naloxone, pretreatment significantly inhibited the antinociceptive activity of ORG and morphine.
Conclusion: The aqueous extract of ORG possesses antinociceptive activities in the tail-flick test in a dose dependent manner. ORG - induced antinociception may have been mediated by opioid systems.

 
Keyword(s): INTRACEREBROVENTRICULAR, ORIGANUM VULGARE, PAIN, RAT, TAIL-FLICK TEST
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 73
 
Latest on Blog
Enter SID Blog