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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JANUARY 2014 , Volume 17 , Number 1; Page(s) 69 To 72.
 
Paper: 

NEPHROPROTECTIVE EFFECTS OF FEIJOA SELLOWIANA LEAVES EXTRACT ON RENAL INJURY INDUCED BY ACUTE DOSE OF ECSTASY (MDMA) IN MICE

 
 
Author(s):  KARAMI MOHAMMAD*, KARIMIAN NOKABADI FAEZEH, EBRAHIMZADEH MOHAMMAD ALI, NAGHSHVAR FARSHAD
 
* DEPARTMENT OF TOXICOPHARMACOLOGY, SCHOOL OF PHARMACY, MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, SARI, IRAN
 
Abstract: 
Objective(s): Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used.Results: Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P<0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P<0.001 compared to MDMA group). Methanol extract showed higher protective activity in histopathology study.Conclusion: F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.
 
Keyword(s): ECSTASY, FEIJOA SELLOWIANA, KIDNEY GLUTATHIONE, MDMA, NEPHROTOXICITY
 
 
References: 
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APA: Copy

KARAMI, M., & KARIMIAN NOKABADI, F., & EBRAHIMZADEH, M., & NAGHSHVAR, F. (2014). NEPHROPROTECTIVE EFFECTS OF FEIJOA SELLOWIANA LEAVES EXTRACT ON RENAL INJURY INDUCED BY ACUTE DOSE OF ECSTASY (MDMA) IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(1), 69-72. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405533



Vancouver: Copy

KARAMI MOHAMMAD, KARIMIAN NOKABADI FAEZEH, EBRAHIMZADEH MOHAMMAD ALI, NAGHSHVAR FARSHAD. NEPHROPROTECTIVE EFFECTS OF FEIJOA SELLOWIANA LEAVES EXTRACT ON RENAL INJURY INDUCED BY ACUTE DOSE OF ECSTASY (MDMA) IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021December02];17(1):69-72. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405533



IEEE: Copy

KARAMI, M., KARIMIAN NOKABADI, F., EBRAHIMZADEH, M., NAGHSHVAR, F., 2014. NEPHROPROTECTIVE EFFECTS OF FEIJOA SELLOWIANA LEAVES EXTRACT ON RENAL INJURY INDUCED BY ACUTE DOSE OF ECSTASY (MDMA) IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(1), pp.69-72. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405533.



 
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