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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JANUARY 2014 , Volume 17 , Number 1; Page(s) 69 To 72.
 
Paper: 

NEPHROPROTECTIVE EFFECTS OF FEIJOA SELLOWIANA LEAVES EXTRACT ON RENAL INJURY INDUCED BY ACUTE DOSE OF ECSTASY (MDMA) IN MICE

 
 
Author(s):  KARAMI MOHAMMAD*, KARIMIAN NOKABADI FAEZEH, EBRAHIMZADEH MOHAMMAD ALI, NAGHSHVAR FARSHAD
 
* DEPARTMENT OF TOXICOPHARMACOLOGY, SCHOOL OF PHARMACY, MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, SARI, IRAN
 
Abstract: 

Objective(s): Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.
Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used.
Results: Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P<0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P<0.001 compared to MDMA group). Methanol extract showed higher protective activity in histopathology study.
Conclusion: F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.

 
Keyword(s): ECSTASY, FEIJOA SELLOWIANA, KIDNEY GLUTATHIONE, MDMA, NEPHROTOXICITY
 
References: 
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