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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   OCTOBER 2013 , Volume 16 , Number 10; Page(s) 1065 To 1070.
 
Paper: 

TERATOGENIC EFFECTS OF PREGABALIN IN MICE

 
 
Author(s):  ETEMAD LEILA, MOHAMMAD AFSHAR, MOHAMMADPOUR AMIR HOUSHANG, VAHDATI MASHHADI NASSER, MOALLEM SEYED ADEL*
 
* DEPARTMENT OF PHARMACODYNAMICS AND TOXICOLOGY, SCHOOL OF PHARMACY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective (s): Anti-epileptic drugs (AEDs) have the potential to affect fetal development throughout pregnancy. Considering the broad therapeutic indications of pregabalin (PGB), its potential teratogenic effects and the levels of homocysteine have been studied.
Materials and Methods: Timed-pregnant mice received one of three doses of PGB (20, 40 or 80 mg/kg/day) or the vehicle control during organogenesis, intraperitoneally. The litters were stained and examined for malformations. Total homocysteine (tHcy) was measured in serum from the pregnant mice on GD18.
Results: The rate of fetus malformations increased significantly in all treated groups as compared to the control group. The abnormalities included limb, vertebral column and craniofacial abnormalities. The most common abnormality was limb deformity. The percentage of fetal resorption significantly increased at higher doses. There was no significant difference in tHcy concentrations between the treated and control groups.
Conclusion: Pregabalin may have potential teratogenic effects even in lower doses, however with less intensity than other AEDs. Therefore, it is suggested that great caution should be taken when prescribing it in pregnancy and further investigation for possible mechaninsms.

 
Keyword(s): ANTIEPILEPTIC DRUGS, DEVELOPMENTAL TOXICITY, HOMOCYSTEINE, TERATOGENICITY
 
 
References: 
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Click to Cite.
APA: Copy

ETEMAD, L., & MOHAMMAD, A., & MOHAMMADPOUR, A., & VAHDATI MASHHADI, N., & MOALLEM, S. (2013). TERATOGENIC EFFECTS OF PREGABALIN IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(10), 1065-1070. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405531



Vancouver: Copy

ETEMAD LEILA, MOHAMMAD AFSHAR, MOHAMMADPOUR AMIR HOUSHANG, VAHDATI MASHHADI NASSER, MOALLEM SEYED ADEL. TERATOGENIC EFFECTS OF PREGABALIN IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May12];16(10):1065-1070. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405531



IEEE: Copy

ETEMAD, L., MOHAMMAD, A., MOHAMMADPOUR, A., VAHDATI MASHHADI, N., MOALLEM, S., 2013. TERATOGENIC EFFECTS OF PREGABALIN IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(10), pp.1065-1070. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405531.



 
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