Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2014 , Volume 17 , Number 5; Page(s) 318 To 321.
 
Paper: 

VALUES OF TROPONIN T AND MYOGLOBIN PREDICTIVE OF NON-CARDIAC ISCHEMIA IN RATS

 
 
Author(s):  GUCLU ORKUT*, CALISKAN AHMET, KARAHAN OGUZ, DEMIRTAS SINAN, YAZICI SULEYMAN, YAVUZ CELAL, MAVITAS BINALI
 
* MEDICAL SCHOOL OF DICLE UNIVERSITY, DEPARTMENT OF CARDIOVASCULAR SURGERY, DIYARBAKIR, TURKEY
 
Abstract: 

Objective (s): Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient. Therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in non-cardiac ischemia.
Materials and Methods: Forty-eight rats were equally divided into six groups. Group I was the control group. Group II was the sham group and received a simple laparotomy. The superior mesenteric artery was clamped in groups III and IV in order to create mesenteric ischemia. The left femoral artery was clamped in groups V and VI in order to create peripheral ischemia. Intracardiac blood samples were taken from all groups (during the 3rd hour of ischemia in groups III and V and the 6th hour of ischemia in group IV and VI) and troponin T and myoglobin levels were measured.
Results: Troponin and myoglobin levels were statistically similar in groups I and II. Moreover, increments were detected for troponin and myoglobin in ischemia groups according to group I and II. Furthermore, higher troponin Tlevels were detected after three hours of mesenteric ischemia and higher myoglobin values were observed after six hours of mesenteric ischemia (P<0.05).
Conclusion: Troponin T and myoglobin are not specific for non-cardiac ischemia, and they may be useful for detecting other ischemic events.

 
Keyword(s): MESENTERIC ISCHEMIA, MYOGLOBIN, PERIPHERAL ISCHEMIA, TROPONIN T
 
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