Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY 2013 , Volume 16 , Number 7; Page(s) 841 To 844.
 
Paper: 

APOLIPOPROTEIN E GENE POLYMORPHISM IN IRANIAN CORONARY ATHEROSCLEROSIS PATIENTS CANDIDATE FOR CORONARY ARTERY BYPASS GRAFT

 
 
Author(s):  HEIDARI MOHAMMAD MEHDI*, FORUZANNIA SEYED KHALIL, KHATAMI MEHRI, HADADZADEH MEHDI, EMAMI MEYBODI MAHMOUD
 
* DEPARTMENT OF BIOLOGY, SCIENCE SCHOOL, YAZD UNIVERSITY, YAZD, IRAN
 
Abstract: 

Objective (s): Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the Apolipoprotein E genotypes with coronary artery disease in the Iranian population.
Materials and Methods: The Apolipoprotein E genotype in DNA samples extracted from 66 CAD+ patients and 61 control subjects by restricting enzyme digestion of amplified exon 4 APOE gene was determined.
Results: The ?3 allele was found at similar frequency in control subjects (88.5%) and atherosclerosis patients (83.3%) (P=0.314). Our results showed that the frequency of the
e3/e3 and e3/e4 genotypes increased in three-vessel-disease patients and the frequency of e2/e2 genotype increased in one-vessel-disease patients.
Conclusion:
e3/e3 and e3/e4 genotypes are suggested to be predisposing factors, which, in combination with environmental factors, may trigger the degree of luminal narrowing. The possible mechanisms remain elusive and require further studies.

 
Keyword(s): APOLIPOPROTEIN E, CORONARY ATHEROSCLEROSIS, POLYMORPHISM, RESTRICTION ISOTYPING
 
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