Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JANUARY 2014 , Volume 17 , Number 1; Page(s) 55 To 61.
 
Paper: 

EFFECTS OF ADMINISTRATION OF HISTAMINE AND ITSH1, H2, AND H3 RECEPTOR ANTAGONISTS INTO THE PRIMARY SOMATOSENSORY CORTEX ON INFLAMMATORY PAIN IN RATS

 
 
Author(s):  TAMADDONFARD ESMAEAL*, HAMZEH GOOSHCHI NASRIN
 
* DEPARTMENT OF BASIC SCIENCES, FACULTY OF VETERINARY MEDICINE, URMIA UNIVERSITY, URMIA, IRAN
 
Abstract: 

Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain.
Material and Methods: Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inflammatory pain was induced by subcutaneous (SC) injection of formalin (50
ml, 2.5%) in the ventral surface of right hind paw. Time durations of licking/biting of the injected paw were recorded as a pain measure.
Results: Formalin produced a biphasic pattern of licking/biting of the injected paw. Histamine at doses of 0.5, 1, and 2
mg decreased the intensity of pain. Chlorpheniramine and ranitidine at the same doses of 1 and 4 mg had no effects, whereas thioperamide at a dose of 4 mg suppressed both phases of formalin-induced pain. Pretreatments with chlorpheniramine and ranitidine at the same dose of 4 mg prevented histamine (2 mg)-induced antinociception. Antinociceptive effects were observed when thioperamide at doses of 1 and 4 mg was used with 0.25 and 1 mg of histamine, respectively. The antinociceptive effects induced by histamine (2 mg) and thioperamide (4 mg) were prevented by prior treatment with naloxone (4 mg).
Conclusion: These results indicate that at PSC levels, histamine through post-synaptic H1, H2, and pre-synaptic H3 receptors might be involved in pain modulation. The endogenous opioid system may be involved in histamine- and thioperamide-induced antinociception.

 
Keyword(s): FORMALIN-INDUCED PAIN HISTAMINE, HISTAMINE RECEPTOR ANTAGONISTS, PRIMARY SOMATOSENSORY CORTEX, RATS
 
 
References: 
  • ندارد
  •  
 
Click to Cite.
APA: Copy

TAMADDONFARD, E., & HAMZEH GOOSHCHI, N. (2014). EFFECTS OF ADMINISTRATION OF HISTAMINE AND ITSH1, H2, AND H3 RECEPTOR ANTAGONISTS INTO THE PRIMARY SOMATOSENSORY CORTEX ON INFLAMMATORY PAIN IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(1), 55-61. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405513



Vancouver: Copy

TAMADDONFARD ESMAEAL, HAMZEH GOOSHCHI NASRIN. EFFECTS OF ADMINISTRATION OF HISTAMINE AND ITSH1, H2, AND H3 RECEPTOR ANTAGONISTS INTO THE PRIMARY SOMATOSENSORY CORTEX ON INFLAMMATORY PAIN IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May14];17(1):55-61. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405513



IEEE: Copy

TAMADDONFARD, E., HAMZEH GOOSHCHI, N., 2014. EFFECTS OF ADMINISTRATION OF HISTAMINE AND ITSH1, H2, AND H3 RECEPTOR ANTAGONISTS INTO THE PRIMARY SOMATOSENSORY CORTEX ON INFLAMMATORY PAIN IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(1), pp.55-61. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405513.



 
  pdf-File
Yearly Visit 55
 
Latest on Blog
Enter SID Blog