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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JANUARY 2014 , Volume 17 , Number 1; Page(s) 49 To 54.
 
Paper: 

ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION

 
 
Author(s):  EBRAHIMI HOSSEIN, REZAEE SEYYED ABDOLRAHIM, VALIZADEH NARGES, VAKILI ROSITA, RAFATPANAH HOUSHANG*
 
* INFLAMMATION AND INFLAMMATORY DISEASES RESEARCH CENTER, FACULTY OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV-I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.
Materials and Methods: In this study, 40 subjects were selected; 14 HIV infected, 20 HTLV-I infected and 6 HTLV-I/HIV co-infected subjects. The amount of viruses was measured using qPCR TaqMan method and CD4 and CD8 lymphocytes were assessed by flow cytometry.
Results: The mean viral load of HIV infected subjects and HTLV-I infected individuals were 134626.07±60031.07 copies/ml and 373.6±143.3 copies/104 cells, respectively. The mean HIV viral load in co-infected group was 158947±78203.59 copies/ml which is higher than HIV infected group. The mean proviral load of HTLV-I in co-infected group was 222.33±82.56 copies/ml which is lower than HTLV-I infected group (P<0.05). Also, the mean white blood cell count was higher in co-infected group (5666.67±1146.49 cells/
ml). However, the differences between these subjects did not reach to a statistical significance within 95% confidence interval level (P =0.1). No significant differences were observed regarding CD4 and CD8 positive lymphocytes between these groups.
Conclusion: HTLV-I/HIV co-infection might promote HIV replication and could reduce the HTLV-I proviral load, in infected cells. Considering the presence of both viruses in Khorasan provinces, it encourages researchers and health administrators to have a better understanding of co-infection outcome.

 
Keyword(s): HIV VIRAL LOAD, HTLV-I/HIV CO-INFECTION, HTLV-I PROVIRAL LOAD, LYMPHOCYTES
 
 
References: 
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APA: Copy

EBRAHIMI, H., & REZAEE, S., & VALIZADEH, N., & VAKILI, R., & RAFATPANAH, H. (2014). ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(1), 49-54. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405502



Vancouver: Copy

EBRAHIMI HOSSEIN, REZAEE SEYYED ABDOLRAHIM, VALIZADEH NARGES, VAKILI ROSITA, RAFATPANAH HOUSHANG. ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May18];17(1):49-54. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405502



IEEE: Copy

EBRAHIMI, H., REZAEE, S., VALIZADEH, N., VAKILI, R., RAFATPANAH, H., 2014. ASSESSMENT OF HTLV-I PROVIRAL LOAD, HIV VIRAL LOAD AND CD4 T CELL COUNT IN INFECTED SUBJECTS; WITH AN EMPHASIS ON VIRAL REPLICATION IN CO-INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(1), pp.49-54. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405502.



 
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