Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   NOVEMBER 2013 , Volume 16 , Number 11; Page(s) 1151 To 1154.
 
Paper: 

EXPRESSION AND CLINICAL SIGNIFICANCE OF ACTIVATING TRANSCRIPTION FACTOR 3 IN HUMAN BREAST CANCER

 
 
Author(s):  CAO HUA, YANG ZHI XUE, JIANG GUO QIN*
 
*  1055 SANXIANG ROAD, SUZHOU, 215004, CHINA. DEPARTMENT OF GENERAL SURGERY, THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY, SUZHOU, JIANGSU, CHINA
 
Abstract: 

Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.
Materials and Methods: ATF3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent normal tissues using immunohistochemistry (IHC) assay. Categorical variables were statistically compared by chi-square or Fisher’s exact test. Survival curves were evaluated using the Kaplan-Meier method and comparisons of survival rates were tested using a Log-rank test.
Results: IHC analysis showed that the positive expression of ATF3 protein was detected in breast cancer tissue with a positive ratio of 76.3%, and the positive ATF3 expression in adjacent normal breast tissue was 13.2%, which is lower than that in breast cancer tissue samples (P<0.01). Furthermore, ATF3 expression showed significant correlation with TNM stage, invasion, lymph node metastasis and number of metastatic lymph nodes (P=0.038, P=0.029, P=0.026, and P=0.039 respectively), and did not correlate with patients’ age and tumor size (P>0.05). A significant difference in overall survival rate was found between the patients with positive expression of ATF3 protein and those with negative expression (P=0.041).
Conclusion: Increased ATF3 expression participate in the tumorigenesis, invasion and metastasis of breast cancer, and ATF3 may be useful as a new prognostic indicator for breast cancer patients.

 
Keyword(s): ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3), BREAST CANCER, CLINICAL SIGNIFICANCE, IMMUNOHISTOCHEMISTRY, PROGNOSTIC INDICATOR
 
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