Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2014 , Volume 17 , Number 6; Page(s) 426 To 432.
 
Paper: 

ENZYME INHIBITORY AND RADICAL SCAVENGING EFFECTS OF SOME ANTIDIABETIC PLANTS OF TURKEY

 
 
Author(s):  ORHAN NILUFER, HOSBAS SANEM, ORHAN DIDEM DELIORMAN*, ASLAN MUSTAFA, ERGUN FATMA
 
* DEPARTMENT OF PHARMACOGNOSY, FACULTY OF PHARMACY, GAZI UNIVERSITY, 06330 HIPODROM, ANKARA, TURKEY
 
Abstract: 
Objective(s): Ethnopharmacological field surveys demonstrated that many plants, such as Gentiana olivieri, Helichrysum graveolens, Helichrysum plicatum ssp. plicatum, Juniperus oxycedrus ssp. oxycedrus, Juniperus communis var. saxatilis, Viscum album (ssp. album, ssp. austriacum), are used as traditional medicine for diabetes in different regions of Anatolia. The present study was designed to evaluate the in vitro antidiabetic effects of some selected plants, tested in animal models recently.
Materials and Methods:
a-glucosidase and ?-amylase enzyme inhibitory effects of the plant extracts were investigated and Acarbose was used as a reference drug. Additionally, radical scavenging capacities were determined using 2, 2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ABTS radical cation scavenging assay and total phenolic content of the extracts were evaluated using Folin Ciocalteu method.
Results: H. graveolens ethanol extract exhibited the highest inhibitory activity (55.7%±2.2) on
a-amylase enzyme. Additionally, J. oxycedrus hydro-alcoholic leaf extract had potent a-amylase inhibitory effect, while the hydro-alcoholic extract of J. communis fruit showed the highest a-glucosidase inhibitory activity (IC50: 4.4 mg/ml).
Conclusion: Results indicated that, antidiabetic effect of hydro-alcoholic extracts of H. graveolens capitulums, J. communis fruit and J. oxycedrus leaf might arise from inhibition of digestive enzymes.
 
Keyword(s): α-AMYLASE, α-GLUCOSIDASE, GENTIANA OLIVIER, HELICHRYSUM, JUNIPERUS, VISCUM ALBUM
 
References: 
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