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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2014 , Volume 17 , Number 6; Page(s) 465 To 469.
 
Paper: 

EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION

 
 
Author(s):  RAHIMZADEH MAHSA*, JAHANSHAHI SAMANEH, MOEIN SOHEILA, MOEIN MAHMOOD REZA
 
* MOLECULAR MEDICINE RESEARCH CENTER, DEPARTMENT OF BIOCHEMISTRY, FACULTY OF MEDICINE, HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES, BANDAR ABBAS, IRAN
 
Abstract: 

Objective(s): One strategy for the treatment of diabetes is inhibition of pancreatic a- amylase. Plants contains different chemical constituents with potential for inhibition of a-amylase and hence maybe used as therapeutic.
Materials and Methods: Urtica dioica and Juglans regia Linn were tested for a-amylase inhibition. Different concentrations of leaf aqueous extracts were incubated with enzyme substrate solution and the activity of enzyme was measured. For determination of the type of inhibition, Dixon plot was depicted. Acarbose was used as the standard inhibitor.
Results: Both plant extracts showed time and concentration dependent inhibition of
a-amylase. 60% inhibition was seen with 2 mg/ml of U. dioica and 0.4 mg/ml of J. regia aqueous extract. Dixon plots revealed the type of a-amylase inhibition by these two extracts as competitive inhibition.
Conclusion: Determination of the type of
a-amylase inhibition by these plant extracts could provide by successful use of plant chemicals as drug targets.

 
Keyword(s): AMYLASE INHIBITION, DIABETES, PLANT EXTRACT
 
 
References: 
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Click to Cite.
APA: Copy

RAHIMZADEH, M., & JAHANSHAHI, S., & MOEIN, S., & MOEIN, M. (2014). EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 465-469. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405482



Vancouver: Copy

RAHIMZADEH MAHSA, JAHANSHAHI SAMANEH, MOEIN SOHEILA, MOEIN MAHMOOD REZA. EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May12];17(6):465-469. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405482



IEEE: Copy

RAHIMZADEH, M., JAHANSHAHI, S., MOEIN, S., MOEIN, M., 2014. EVALUATION OF ALPHA- AMYLASE INHIBITION BY URTICA DIOICA AND JUGLANS REGIA EXTRACTS; SHORT COMMUNICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(6), pp.465-469. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405482.



 
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