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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   NOVEMBER 2013 , Volume 16 , Number 11; Page(s) 1119 To 1132.
 
Paper: 

PATHOGENESIS OF EPILEPSY: CHALLENGES IN ANIMAL MODELS

 
 
Author(s):  YIN YOW HUI, AHMAD NURULUMI, MAKMOR BAKRY MOHD*
 
* FACULTY OF PHARMACY, UNIVERSITY KEBANGSAAN MALAYSIA, JALAN RAJA MUDA ABDUL AZIZ, KUALA LUMPUR 50300, MALAYSIA
 
Abstract: 

Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.

 
Keyword(s): ANIMAL MODELS, EPILEPTOGENESIS, PATHOGENESIS OF EPILEPSY, TEMPORAL LOBE EPILEPSY
 
 
References: 
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Click to Cite.
APA: Copy

YIN, Y., & AHMAD, N., & MAKMOR BAKRY, M. (2013). PATHOGENESIS OF EPILEPSY: CHALLENGES IN ANIMAL MODELS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(11), 1119-1132. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405473



Vancouver: Copy

YIN YOW HUI, AHMAD NURULUMI, MAKMOR BAKRY MOHD. PATHOGENESIS OF EPILEPSY: CHALLENGES IN ANIMAL MODELS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May15];16(11):1119-1132. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405473



IEEE: Copy

YIN, Y., AHMAD, N., MAKMOR BAKRY, M., 2013. PATHOGENESIS OF EPILEPSY: CHALLENGES IN ANIMAL MODELS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(11), pp.1119-1132. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405473.



 
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