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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   OCTOBER-DESEMBER 2014 , Volume 8 , Number 3; Page(s) 235 To 242.
 
Paper: 

PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

 
 
Author(s):  FOROOZANFARD FATEMEH, SABERI HAMIDREZA, MORAVEJI SEYED ALIREZA, BAZARGANIPOUR FATEMEH
 
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Abstract: 

Background: To assess the efficacy of luteal phase support (LPS) using intravaginal progesterone (P) on pregnancy rate in Iranian women with polycystic ovarian syndrome (PCOS) who used a combination for ovulation induction consisting of letrozole or clomiphene citrate (CC) and human menopausal gonadotropin (HMG).
Materials and Methods: This was a randomized clinical trial undertaken in a fertility clinic in Kashan, Isfahan Province, Iran. A total of 198 patients completed treatment and follow up. Base on chosen ovulation induction programs, they were divided into two following group: i. CC group (n=98) used a combination consisting of CC (100 mg×5 day) and HMG (150 IU×5 day) and ii. letrozole group (n=100) used a combination consisting of letrozole (5 mg×5 day) and HMG (150 IU×5 day). After human chorionic gonadotropin (hCG) administration (5000 IU), the patients (n=122) who randomly received intravaginal P (Cyclogest, 400 mg daily) were included in LPS group, while the rest (n=123) were included in non-P cycles group. The outcome was the comparison of chemical pregnancy rate between the groups.
Results: Our findings showed that LPS was associated with a 10% higher pregnancy rate than in non-P cycles, although this difference did not reach statistical significant (p=0.08). LPS improved pregnancy rate in both CC (4%) and letrozole (6%) groups. In addition, patients who used letrozole for ovulation induction along with intravaginal P showed higher pregnancy rates than CC group.
Conclusion: Administration of vaginal P for LPS may improve the pregnancy rate in women with PCOS using letrozole or CC in combination with HMG for ovulation induction (Registration Number: IRCT201206072967N4).

 
Keyword(s): CLOMIPHENE, LETROZOLE, PROGESTERONE, LUTEAL PHASE, POLYCYSTIC OVARIAN SYNDROME
 
 
References: 
 
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APA: Copy

FOROOZANFARD, F., & SABERI, H., & MORAVEJI, S., & BAZARGANIPOUR, F. (2014). PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 8(3), 235-242. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405471



Vancouver: Copy

FOROOZANFARD FATEMEH, SABERI HAMIDREZA, MORAVEJI SEYED ALIREZA, BAZARGANIPOUR FATEMEH. PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2014 [cited 2021May18];8(3):235-242. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405471



IEEE: Copy

FOROOZANFARD, F., SABERI, H., MORAVEJI, S., BAZARGANIPOUR, F., 2014. PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 8(3), pp.235-242. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405471.



 
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