Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2014 , Volume 17 , Number 6; Page(s) 460 To 464.
 
Paper: 

ANTIOXIDANT EFFECTS OF PROANTHOCYANIDIN FROM GRAPE SEED ON HEPATIC TISSUE INJURY IN DIABETIC RATS

 
 
Author(s):  MANSOURI ESRAFIL*, KHORSANDI LAYASADAT, ABEDI HASSAN ALI
 
* DEPARTMENT OF ANATOMICAL SCIENCES, CELLULAR AND MOLECULAR RESEARCH CENTER, FACULTY OF MEDICAL SCIENCES, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Objective(s): Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats.
Materials and Methods: Thirty male Sprague-Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks.
Results: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats.
Conclusion: GSP have protective effects against hepatic tissue injury due to antioxidant properties.

 
Keyword(s): ANTIOXIDANT ENZYME, DIABETES, GSP, HEPATIC TISSUE
 
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