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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2013 , Volume 16 , Number 5; Page(s) 719 To 725.
 
Paper: 

PRODUCTION, QUALITY CONTROL AND BIOLOGICAL EVALUATION OF 166HO-PDTMP AS A POSSIBLE BONE PALLIATION AGENT

 
 
Author(s):  ZOLGHADRI SAMANEH, JALILIAN AMIR REZA*, NASERI ZOHREH, YOUSEFNIA HASSAN, BAHRAMI SAMANI ALI, GHANNADI MARAGHEH MOHAMMAD, AFARIDEH HOSSEIN
 
* RADIOPHARMACEUTICAL RESEARCH AND DEVELOPMENT LABORATORY (RRDL), NUCLEAR SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE (NSTRI), TEHRAN, IRAN
 
Abstract: 

Objective(s): In this study, 166Ho-1, 2-propylene di-amino tetra (methy1enephosphonicAcid) (166Ho-PDTMP) complex was prepared as a bone palliation agent.
Materials and Methods: The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1×1013 n.cm-2.s-1) of natural Ho(NO3)3 samples followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed.
Results: The complex was prepared with the specific activity of 278 GBq/mg and high radiochemical purity (>99%, checked by ITLC). 166Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (>90%) up to 72 hr. The biodistribution of 166Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to 48 hr compared to 166HoCl3.
Conclusion: The produced 166Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.

 
Keyword(s): BIODISTRIBUTION, 166HO, PDTMP, RADIOPHARMACEUTICAL, THERAPY
 
 
References: 
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Click to Cite.
APA: Copy

ZOLGHADRI, S., & JALILIAN, A., & NASERI, Z., & YOUSEFNIA, H., & BAHRAMI SAMANI, A., & GHANNADI MARAGHEH, M., & AFARIDEH, H. (2013). PRODUCTION, QUALITY CONTROL AND BIOLOGICAL EVALUATION OF 166HO-PDTMP AS A POSSIBLE BONE PALLIATION AGENT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(5), 719-725. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405459



Vancouver: Copy

ZOLGHADRI SAMANEH, JALILIAN AMIR REZA, NASERI ZOHREH, YOUSEFNIA HASSAN, BAHRAMI SAMANI ALI, GHANNADI MARAGHEH MOHAMMAD, AFARIDEH HOSSEIN. PRODUCTION, QUALITY CONTROL AND BIOLOGICAL EVALUATION OF 166HO-PDTMP AS A POSSIBLE BONE PALLIATION AGENT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May10];16(5):719-725. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405459



IEEE: Copy

ZOLGHADRI, S., JALILIAN, A., NASERI, Z., YOUSEFNIA, H., BAHRAMI SAMANI, A., GHANNADI MARAGHEH, M., AFARIDEH, H., 2013. PRODUCTION, QUALITY CONTROL AND BIOLOGICAL EVALUATION OF 166HO-PDTMP AS A POSSIBLE BONE PALLIATION AGENT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(5), pp.719-725. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405459.



 
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