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Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   SEPTEMBER 2013 , Volume 16 , Number 9; Page(s) 1022 To 1026.
 
Paper: 

The Extract Of Crocus Sativus And Its Constituent Safranal, Affect Serum Levels Of Endothelin And Total Protein In Sensitized Guinea Pigs

 
 
Author(s):  Gholamnezhad Zahra, Koushyar Hamed, Byrami Goltaj, Boskabady Mohammad Hossein*
 
* SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 
Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6, for all groups) and serum levels of endotheline-1 (ET-1) and total protein (TP) were assessed.Results: Serum levels of ET-1 and TP in group S were significantly higher than control group (P<0.01 for ET-1 and P<0.001 TP). Treatment of S animals with dexamethasone, most concentrations of the extract and safranal significantly reduced serum levels of ET-1 and TP compared to group S (P<0.01 to P<0.001). The effects of one concentration of the extract and safranal were significantly higher than dexamethasone (P<0.05 to P<0.01).Conclusion: A preventive effect of the extract of C. sativus and its constituent safranal on serum inflammatory markers in sensitized guinea pigs was shown.
 
Keyword(s): ASTHMA, CROCUS SATIVUS, ENDOTHELINE, INFLAMMATION, SAFRANAL, SENSITIZATION
 
 
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APA: Copy

GHOLAMNEZHAD, Z., & KOUSHYAR, H., & BYRAMI, G., & BOSKABADY, M. (2013). THE EXTRACT OF CROCUS SATIVUS AND ITS CONSTITUENT SAFRANAL, AFFECT SERUM LEVELS OF ENDOTHELIN AND TOTAL PROTEIN IN SENSITIZED GUINEA PIGS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(9), 1022-1026. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405454



Vancouver: Copy

GHOLAMNEZHAD ZAHRA, KOUSHYAR HAMED, BYRAMI GOLTAJ, BOSKABADY MOHAMMAD HOSSEIN. THE EXTRACT OF CROCUS SATIVUS AND ITS CONSTITUENT SAFRANAL, AFFECT SERUM LEVELS OF ENDOTHELIN AND TOTAL PROTEIN IN SENSITIZED GUINEA PIGS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2022July01];16(9):1022-1026. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405454



IEEE: Copy

GHOLAMNEZHAD, Z., KOUSHYAR, H., BYRAMI, G., BOSKABADY, M., 2013. THE EXTRACT OF CROCUS SATIVUS AND ITS CONSTITUENT SAFRANAL, AFFECT SERUM LEVELS OF ENDOTHELIN AND TOTAL PROTEIN IN SENSITIZED GUINEA PIGS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(9), pp.1022-1026. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405454.



 
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