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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   SEPTEMBER 2013 , Volume 16 , Number 9; Page(s) 1022 To 1026.
 
Paper: 

THE EXTRACT OF CROCUS SATIVUS AND ITS CONSTITUENT SAFRANAL, AFFECT SERUM LEVELS OF ENDOTHELIN AND TOTAL PROTEIN IN SENSITIZED GUINEA PIGS

 
 
Author(s):  GHOLAMNEZHAD ZAHRA, KOUSHYAR HAMED, BYRAMI GOLTAJ, BOSKABADY MOHAMMAD HOSSEIN*
 
* SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.
Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6, for all groups) and serum levels of endotheline-1 (ET-1) and total protein (TP) were assessed.
Results: Serum levels of ET-1 and TP in group S were significantly higher than control group (P<0.01 for ET-1 and P<0.001 TP). Treatment of S animals with dexamethasone, most concentrations of the extract and safranal significantly reduced serum levels of ET-1 and TP compared to group S (P<0.01 to P<0.001). The effects of one concentration of the extract and safranal were significantly higher than dexamethasone (P<0.05 to P<0.01).
Conclusion: A preventive effect of the extract of C. sativus and its constituent safranal on serum inflammatory markers in sensitized guinea pigs was shown.

 
Keyword(s): ASTHMA, CROCUS SATIVUS, ENDOTHELINE, INFLAMMATION, SAFRANAL, SENSITIZATION
 
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