Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY 2014 , Volume 17 , Number 7; Page(s) 541 To 545.
 
Paper: 

THE EFFECTS OF EUCHEUMA COTTONII ON ALVEOLAR MACROPHAGES AND MALONDIALDEHYDE LEVELS IN BRONCHOALVEOLAR LAVAGE FLUID IN CHRONICALLY PARTICULATE MATTER 10 COAL DUST-EXPOSED RATS

 
Author(s):  KISNO SAPUTRI ROMADHIYANA, SETIAWAN BAMBANG*, NUGRAHENNY DIAN, KANIA NIA, WAHYUNI ENDANG SRI, WIDODO M ARIS
 
* DEPARTMENT OF MEDICAL CHEMISTRY AND BIOCHEMISTRY, RESEARCH CENTER FOR TOXICOLOGY, CANCER AND DEGENERATIVE DISEASE, MEDICAL FACULTY, LAMBUNG MANGKURAT UNIVERSITY, JL. VETERAN, BANJARMASIN, SOUTH KALIMANTAN, INDONESIA
 
Abstract: 

Objective (s): To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats.
Materials and Methods: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m3 (CD25) an hour daily for 6 months with or without supplementation of ethanolic extract of E. cottonii at doses of 150 (EC150) or 300 mg/kg BW (EC300). The number of macrophages was determined using a light microscope. MDA levels were measured by TBARS assay.
Results: EC150 insignificantly (P>0.05) reduces the AM in CD groups compared to non treatment groups. EC150 and EC300 significantly (P<0.05) decreased MDA levels in CD12.5 and CD25 groups relative to non treatment groups.
Conclusion: E. cottoniiattenuated oxidative stress in chronic exposure of PM10 coal dust.

 
Keyword(s): ALVEOLAR MACROPHAGE, COAL DUST, EUCHEUMA COTTONII, MALONDIALDEHYDE
 
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