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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MAY 2013 , Volume 16 , Number 5; Page(s) 705 To 709.
 
Paper: 

DEVELOPMENT OF 177LU-PHYTATE COMPLEX FOR RADIOSYNOVECTOMY

 
 
Author(s):  YOUSEFNIA HASSAN, JALILIAN AMIR REZA*, BAHRAMI SAMANI ALI, MAZIDI MOHAMMAD, GHANNADI MARAGHEH MOHAMMAD, ABBASI DAVANI FEREYDOUN
 
* RADIOPHARMACEUTICAL RESEARCH AND DEVELOPMENT LAB, NUCLEAR SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE (NSTRI), TEHRAN, IRAN
 
Abstract: 

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation.
Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4×1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of177Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100
mCi/100 ml) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days.
Results: The complex was successfully prepared with high radiochemical purity (>99.9%). Approximately, the whole injected dose has remained in injection site seven days after injection.
Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.

 
Keyword(s): BIODISTRIBUTION, LUTETIUM-177, PHYTATE, RADIOSYNOVECTOMY
 
 
References: 
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Click to Cite.
APA: Copy

YOUSEFNIA, H., & JALILIAN, A., & BAHRAMI SAMANI, A., & MAZIDI, M., & GHANNADI MARAGHEH, M., & ABBASI DAVANI, F. (2013). DEVELOPMENT OF 177LU-PHYTATE COMPLEX FOR RADIOSYNOVECTOMY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(5), 705-709. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405439



Vancouver: Copy

YOUSEFNIA HASSAN, JALILIAN AMIR REZA, BAHRAMI SAMANI ALI, MAZIDI MOHAMMAD, GHANNADI MARAGHEH MOHAMMAD, ABBASI DAVANI FEREYDOUN. DEVELOPMENT OF 177LU-PHYTATE COMPLEX FOR RADIOSYNOVECTOMY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May14];16(5):705-709. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405439



IEEE: Copy

YOUSEFNIA, H., JALILIAN, A., BAHRAMI SAMANI, A., MAZIDI, M., GHANNADI MARAGHEH, M., ABBASI DAVANI, F., 2013. DEVELOPMENT OF 177LU-PHYTATE COMPLEX FOR RADIOSYNOVECTOMY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(5), pp.705-709. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405439.



 
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