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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   AUGUST 2013 , Volume 16 , Number 8; Page(s) 941 To 945.
 
Paper: 

GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE

 
 
Author(s):  TAHERGORABI ZOYA, RASHIDI BAHMAN, KHAZAEI MAJID*
 
* DEPARTMENT OF PHYSIOLOGY, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Objective(s): Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice.
Materials and Methods: This study was conducted on 24 male C57BL/6 mice. The animals were divided into four groups: control, obese (received high fat diet), control+ghrelin (injected with 100
mg/Kg subcutaneously, bid) and obese+ghrelin (n=6 each). After 10 days, animals were sacrificed and epididymal adipose tissue and thoracic aortae were removed. Adipocyte cell number, size and aortic intima-media thickness were evaluated.
Results: Ghrelin did not change adipocyte cell number and size and aortic intima-media thickness in obese and control mice. In this study, high fat diet significantly decreased the number of adipocyte cells while increased their size (P<0.05). Ghrelin administration had no significant effect on adipocyte cell number and size in obese and control groups (P>0.05). In addition, it could not alter aortic intima-media thickness in both groups.
Conclusion: Although ghrelin has several cardiovascular effects, it seems that it could not alter the size and number of adipocyte cells and aortic intima-media thickness in diet-induced obese mice.

 
Keyword(s): ADIPOCYTE, ATHEROSCLEROSIS, GHRELIN, OBESITY
 
 
References: 
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Click to Cite.
APA: Copy

TAHERGORABI, Z., & RASHIDI, B., & KHAZAEI, M. (2013). GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(8), 941-945. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405438



Vancouver: Copy

TAHERGORABI ZOYA, RASHIDI BAHMAN, KHAZAEI MAJID. GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May12];16(8):941-945. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405438



IEEE: Copy

TAHERGORABI, Z., RASHIDI, B., KHAZAEI, M., 2013. GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(8), pp.941-945. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405438.



 
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