Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   SEPTEMBER 2013 , Volume 16 , Number 9; Page(s) 1011 To 1015.
 
Paper: 

ASSOCIATION OF URINARY LIPOCALIN-2 WITH LUPUS NEPHRITIS

 
 
Author(s):  SHARIFIPOUR FARZANEH, ZERAATI ABBAS ALI, SAHEBARI MARYAM, HATEF MOHAMMADREZA, NAGHIBI MASIH, REZAIEYAZDI ZAHRA, MAHMOUDI MAHMOUD, AZARIAN AMIR ABAS, MIRFEIZI ZAHRA*, SAMADI KATAYOUN
 
* RHEUMATIC DISEASES RESEARCH CENTER (RDRC), MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective(s): Lupus nephritis (LN) is the main cause of mortality and disability in systemic lupus erythematosus (SLE) patients. Therefore, utilizing a reliable and non-invasive method for serial measurements of renal function seems to be necessary. The aim of this study was to evaluate the role of urinary lipocalin-2 as a biomarker of renal involvement in SLE patients.
Materials and Methods: Fifty two lupus patients in this cross sectional study were divided into two groups: patients with and without nephritis. For each group, urinary lipocalin-2, values were measured and reported according to urinary lipocalin-2/creatinine. Urinary lipocalin-2/creatinine sensitivity and specificity for identifying biopsy-proven nephritis were calculated, and a receiver operating characteristic (ROC) curve was constructed.
Results: The mean urinary lipocalin-2/creatinine value of patients with biopsy-proven LN was 2.99±4.1 ng/mg, and in non-LN patients was 1.16±1.27 ng/mg. Urinary lipocalin-2/creatinine levels in LN patients were significantly higher than those in non-LN patients (P- Value=0.03). In LN patients, urinary lipocalin-2/creatinine significantly correlated with proteinuria (r=0.68; P=0.0001). Using a cutoff value of 0.896 ng/mg, urinary lipocalin-2/creatinine had a sensitivity of 89.7% and a specificity of 39.1% for identifying SLE patients with biopsy-proven LN. The area under the ROC curve was 0.664 ± 0.076 with a 95% confidence interval of 0.52-0.81 (P=0.04). Analysis of variance showed that urinary lipocalin-2/creatinine is the same in different classes of LN (P-value=0.28).
Conclusion: An important clinical conclusion is that measurement of urinary Lipocalin-2 may result in earlier diagnosis of LN.

 
Keyword(s): LUPUS, NEPHRITIS, SLE, URINARY LIPOCALIN- 2
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 73
 
Latest on Blog
Enter SID Blog