Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JANUARY 2014 , Volume 17 , Number 1; Page(s) 1 To 8.
 
Paper: 

EVALUATION OF IMMUNE RESPONSE AFTER MODERATE AND OVERTRAINING EXERCISE IN WISTAR RAT

 
 
Author(s):  GHOLAMNEZHAD ZAHRA, BOSKABADY MOHAMMAD HOSSEIN*, HOSSEINI MAHMOUD, SANKIAN MOJTABA, KHAJAVI RAD ABOLFAZL
 
* DEPARTEMT OF PHYSIOLOGY, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Objective(s): The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study.
Materials and Methods: Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/min, 60min/day for 6 days a week, 11 weeks) and recovered overtrained (OR) (OT plus 2 weeks recovery) groups, (n=6 for each group). Immediately, 24 hr and 2 weeks (in OR) after last bout of exercise blood samples were obtained. The plasma concentrations of TNF
a, IL-6, IL-10, IL-4 and IFNg were measured by ELISA method.
Results: Immediately after last bout of exercise the following findings were observed; IL-6, IL-10 and TNF?concentrations increased in OT and OR groups compared with control (P<0.05– P<0.001). Serum level of IL-4 decreased (P<0.01) but IFN
g increased (P<0.05) in MT group vs. control. In addition, circulatory levels of TNFa IL-6, IL-10 and IL-4 were higher but the IFNg concentrations were lower in OT and OR groups than MT group (P<0.05- P<0.01). The IFN-gIL4 ratio was significantly increased in MT (P<0.01) while it decreased in OT group. There were not statistical differences in TNFa IL-6, and IFNg levels between different time intervals after exercise in MT, OT and OR groups.
Conclusion: These data confirm a positive effect of moderate exercise on immune function and a decrease in susceptibility to viral infection by inducing Th1 cytokine profile shift. However, prolonged and overtraining exercise causes numerous changes in immunity that possibly reflects physiological stress and immune suppression.

 
Keyword(s): IMMUNE SYSTEM, MODERATE EXERCISE, OVERTRAINING EXERCISE, RAT, TH1, TH2
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 56
 
Latest on Blog
Enter SID Blog