Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   SEPTEMBER 2013 , Volume 16 , Number 9; Page(s) 1004 To 1010.
 
Paper: 

IMPROVEMENT IN MEMORY AND BRAIN LONG-TERM POTENTIATION DEFICITS DUE TO PERMANENT HYPOPERFUSION/ISCHEMIA BY GRAPE SEED EXTRACT IN RATS

 
 
Author(s):  SARKAKI ALIREZA, RAFIEIRAD MARYAM, HOSSINI SEYED EBRAHIM, FARBOOD YAGHOUB*, MOTAMEDI FERESHTEH, MANSOURI SEYED MOHAMMAD TAGHI, NAGHIZADEH BAHAREH
 
* DEPARTMENT OF PHYSIOLOGY AND PHYSIOLOGY RESEARCH CENTER, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ-IRAN
 
Abstract: 

Objective(s): Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long-term potentiation (LTP) after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult rats.
Materials and Methods: Thirty-two adult male Wistar rats were randomly divided into: 1) Sham+Veh, 2) Isch+Veh, 3) Sham+GSE, 4) Isch+GSE. In order to make 2CCAO as an animal model of CHI, carotid arteries were ligatured and then cut bilaterally. To evaluation of passive avoidance memory, step-down latency (STL) was measured and LTP was recorded from hippocampal dentate gyrus (DG) after high frequency stimulation (HFS) in all rats.
Results: We found that memory was significantly impaired in rats after CHI (P<0.001) concomitant with hippocampal LTP inhibition (P<0.05, P<0.01 for LTP1 and LTP48 respectively). GSE treatment significantly improved memory impairment and increased hippocampal LTP in rats with 2CCAO.
Conclusion: Our results in present study suggest that GSE exhibits therapeutic potential for short-and long-term memories as well as LTP in DG, which is most likely related at least in part to its antioxidative and free radical scavenging actions.

 
Keyword(s): GRAPE SEED EXTRACT, HYPOPERFUSION, ISCHEMIA, LTP, MEMORY, RAT
 
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