Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2014 , Volume 17 , Number 6; Page(s) 433 To 440.
 
Paper: 

GENDER DIFFERENCE IN MOTOR IMPAIRMENTS INDUCED BY CHRONIC ADMINISTRATION OF VINBLASTINE

 
 
Author(s):  PARSANIA SHAHRNAZ, SHABANI MOHAMMAD*, MOAZZAMI KASRA, RAZAVINASAB MOAZAMEHOSADAT, LARIZADEH MOHAMMAD HASSAN, NAZERI MASOUD, ASADI SHEKAARI MAJID, KERMANI MOEIN
 
* KERMAN NEUROSCIENCE RESEARCH CENTER, NEUROPHARMACOLOGY INSTITUTE, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Objective(s): Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen.
Materials and Methods: The effects of VBL treatment on motor, learning and memory functions of male and female Wistar rats were studied by behavioral related tests. Animals were given chronic intraperitoneal injections of VBL (0.2 mg/kg/week for 5 weeks) from postnatal day 23 to 52. Motor function was evaluated using grasping test and balancing was evaluated by the rotarod. Spatial learning and memory and anxiety-like behavior were determined using Morris water maze (MWM) task and open field test, respectively.
Results: Administration of VBL caused severe damage to motor and balance function of male rats in comparison to female rats treated with VBL and rats treated with saline. Memory and locomotion were affected in both male and female rats compared with saline treated rats, while a sex difference was also observed in these parameters; male rats showed more impairment compared with female ones. Both male and female rats showed cognitive impairments in MWM task and no sex differences were observed in these functions.
Conclusion: Results revealed that VBL is a potent neurotoxic agent and despite the profound effect of VBL on motor and cognitive functions, it seems that male rats are more susceptible to motor deficits induced by VBL.

 
Keyword(s): ANTICANCER, LEARNING AND MEMORY, MOTOR FUNCTION, VINBLASTINE
 
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