Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2014 , Volume 17 , Number 6; Page(s) 454 To 459.
 
Paper: 

MILD HYPOTHERMIA REDUCES EXPRESSION OF FAS/FASL AND MMP-3 AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS

 
Author(s):  ZHAO JINGKUN, DUAN SHURONG*, ZHOU JINXIA, SUN RUIHONG, ZHANG LIMING, WANG DESHENG
 
* DEPARTMENT OF NEUROLOGY, THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY, CHINA
 
Abstract: 

Objective(s): To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats.
Materials and Methods: Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypothermia (33±0.5
oC) for 6 hr was initiated at the start of reperfusion. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3.
Results: Infarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P<0.05). In mild hypothermia group, numbers of Fas-positive and MMP-3 positive cells were significantly less than those of normothermia group (P<0.05). Neurological functional scores of mild hypothermia were significantly improved (P<0.05).
Conclusion: Mild hypothermia decreases infarct volume after cerebral ischemia-reperfusion, reduces Fas and MMP-3 expression, but increases FasL in cerebral ischemia-reperfusion rats.

 
Keyword(s): CEREBRAL ISCHEMIA/REPERFUSION, FAS, FASL, HYPOTHERMIA, MACO RAT, MMP-3
 
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