Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   SEPTEMBER 2013 , Volume 16 , Number 9; Page(s) 990 To 995.
 
Paper:  GENETIC VARIATIONS OF TUMOR NECROSIS FACTOR -α-308 AND LYMPHTOXIN--α+252 IN NON-HODGKIN LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS
 
Author(s):  NASIRI HAJAR, FARAJNIA SAFAR, REZAMAND AZIM, MOVASSAGHPUOR ALI AKBAR, ESMAEILI HEYDAR ALI, MONFAREDAN AMIR, MOBARRA NASER, RAHIMIFAR NASSER, SAHEBI LEILA, FARSHDOUSTI HAGH MAJID*
 
* HEMATOLOGY AND ONCOLOGY RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Objective (s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-a (TNF-a) -308 and lymphotoxin-a (LT-a) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-a (-308) and LT-a (+252) polymorphisms are different for NHL and ALL cases in various populations with different ethnicity. This research is designed to investigate the prevalence and association of TNF-a (-308) and LT-a (+252) polymorphisms from NHL and ALL in Azarian patients and healthy individuals from Northwestern part of Iran.
Materials and Methods: Seventy subjects with ALL and 68 NHL, along with another 130 healthy subjects as control group took part in this study. Genomic DNA was extracted, then genetic polymorphisms in TNF-
a and LT-a genes were analyzed with the PCR-RFLP and NCOI as restriction enzyme. A statistical analysis was performed by chi-square test using SPSS software. A P-value of<0.05 was considered statistically significant.
Results: A statistically significant difference of LT-
a polymorphism was in NHL patients and control (P-value=0.008) but there was not any association of TNF-a polymorphism between NHL patients and control group. A significant association for TNF-a variant was in ALL and control (P-value=0.005), however, there was no relationship about LT variant between ALL and control.
Conclusion: The results show that there are significant differences between TNF-
a (-308) and LT-a (+252) genetic polymorphisms respectively in ALL and NHL patients with control group from Northwestern part of Iran.

 
Keyword(s): ACUTE LYMPHOCYTIC LEUKE- MIA, LT-α, NON-HODGKIN LYMPHOMA, POLYMORPHISM, TNF-α
 
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