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Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JUN 2014 , Volume 17 , Number 6; Page(s) 411 To 418.
 
Paper: 

The Effects Of Nano-Silver And Garlic Administration During Pregnancy On Neuron Apoptosis In Rat Offspring Hippocampus
 
 
Author(s):  Lale Ataei Maryam, Ebrahimzadeh Bideskan Ali Reza*
 
* DEPARTMENT OF ANATOMY AND CELL BIOLOGY, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 
Materials and Methods: Fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (N.S) group; 30 mg/kg of N.S treated via gavage. 2- Control (C) group, administrated with distilled water via gavage. 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. 4- Garlic group (G); garlic juice (1 ml/100 g) administrated via gavage, 5- normal (N) without any intervention. All the interventions were done during pregnancy (21 days). Finally, the brains of rat offspring were removed to use for nano-silver level measurement and TUNEL staining. The mean of TUNEL positive cell numbers per unit area (NA) in different regions of hippocampus were compared in all animal groups.Results: The results revealed a significant increase of hippocampus nano-silver level in N.S and N.S+G groups comparing to N group (P<0.05) and a significant decrease in nano-silver level in N.S+G group comparing to N.S group (P<0.01). The number of TUNEL positive cells in the CA1, CA3, and DG fields of rat offspring hippocampus increased in N.S and N.S+G groups comparing to other ones, and also reduced significantly in N.S+G group comparing to N.S group (¥ P<0.01).Conclusion: Our results showed that co-administration of nano-silver and garlic during pregnancy may lead to reduce nano-silver induced apoptotic cells in their offspring hippocampus.
 
Keyword(s): APOPTOSIS, GARLIC, HIPPOCAMPUS, NANO-SILVER
 
 
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APA: Copy

LALE ATAEI, M., & EBRAHIMZADEH BIDESKAN, A. (2014). THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 411-418. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405380



Vancouver: Copy

LALE ATAEI MARYAM, EBRAHIMZADEH BIDESKAN ALI REZA. THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2022August14];17(6):411-418. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405380



IEEE: Copy

LALE ATAEI, M., EBRAHIMZADEH BIDESKAN, A., 2014. THE EFFECTS OF NANO-SILVER AND GARLIC ADMINISTRATION DURING PREGNANCY ON NEURON APOPTOSIS IN RAT OFFSPRING HIPPOCAMPUS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(6), pp.411-418. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405380.
 
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